Serum protein and enzyme levels in rats following administration of antioxidant vitamins during caffeinated and non-caffeinated paracetamol induced hepatotoxicity

The effects of caffeinated and non-caffeinated paracetamol administration, with or without vitamins A and E supplementation on the protein and enzyme levels in Wistar albino rats were investigated using caffeinated paracetamol and paracetamol as caffeinated and non-caffeinated paracetamol respective...

Full description

Saved in:
Bibliographic Details
Published in:Nigerian journal of physiological sciences 2007-06, Vol.22 (1-2), p.65-68
Main Authors: Ekam, V S, Ebong, P E
Format: Article
Language:English
Subjects:
Acetaminophen
Alanine Transaminase - blood
Alkaline Phosphatase - blood
Animals
Antioxidants - pharmacology
Aspartate Aminotransferases - blood
Biomarkers - blood
Blood Proteins - metabolism
Caffeine - pharmacology
Chemical and Drug Induced Liver Injury - drug therapy
Chemical and Drug Induced Liver Injury - enzymology
Chemical and Drug Induced Liver Injury - etiology
Chemical and Drug Induced Liver Injury - pathology
Disease Models, Animal
Drug Combinations
Enzymes - blood
Liver - drug effects
Liver - embryology
Liver - pathology
Necrosis
Rats
Rats, Wistar
Vitamin A - pharmacology
Vitamin E - pharmacology
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The effects of caffeinated and non-caffeinated paracetamol administration, with or without vitamins A and E supplementation on the protein and enzyme levels in Wistar albino rats were investigated using caffeinated paracetamol and paracetamol as caffeinated and non-caffeinated paracetamol respectively, and water soluble acetic acid derivatives of vitamins A and E. Serum AST, ALT and ALP levels (u/l) significantly increased [P < 0.05] following paracetamol administration. Caffeination as well as administration of vitamins A and E caused significant decreases[P < 0.05] in AST and ALP levels in all test groups when co-administered with paracetamol and in ALT level except in the caffeinated paracetamol + Vitamin E group in which ALT and ALP level except in the caffeinated paracetamol + vitamin E group in which ALT and ALP levels significantly increased [P < 0.05]. Total serum protein level (g/100ml) significantly increased following caffeination as well as during co-administration of caffeinated paracetamol and Vitamin E; and significantly decreased during co-administration of paracetamol and vitamin A. Paracetamol administration without caffeination or supplementation with vitamin A and E can therefore cause increases in serum liver enzymes that is suggestive of liver necrosis which can be ameliorated to varying degrees by caffeine, vitamin A and E.
ISSN:0794-859X