Enhanced lipid peroxidation and platelet activation in the early phase of type 1 diabetes mellitus: Role of interleukin-6 and disease duration

• Published in: Circulation (New York, N.Y.) N.Y.), 2003-07, Vol.107 (25), p.3199-3203
• Main Authors: DAVI, Giovanni, CHIARELLI, Francesco, SANTILLI, Francesca, POMILIO, Mariapina, VIGNERI, Sergio, FALCO, Angela, BASILI, Stefania, CIABATTONI, Giovanni, PATRONO, Carlo
• Format: Article
• Language: English
• Subjects: Adolescent; Associated diseases and complications; Biological and medical sciences; Biomarkers - analysis; C-Reactive Protein - analysis; Child; Cross-Sectional Studies; Diabetes Mellitus, Type 1 - complications; Diabetes Mellitus, Type 1 - drug therapy; Diabetes Mellitus, Type 1 - physiopathology; Diabetes. Impaired glucose tolerance; Dinoprost - analogs & derivatives; Disease Progression; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; F2-Isoprostanes - biosynthesis; F2-Isoprostanes - urine; Female; Follow-Up Studies; Humans; Inflammation - etiology; Inflammation - physiopathology; Insulin - therapeutic use; Interleukin-6 - blood; Interleukin-6 - metabolism; Lipid Peroxidation; Male; Medical sciences; Oxidative Stress; Platelet Activation; Reference Values; Thromboxane A2 - metabolism; Thromboxane B2 - analogs & derivatives; Thromboxane B2 - urine; Time; Tumor Necrosis Factor-alpha - analysis
• ISSN: 0009-7322; 1524-4539
• DOI: 10.1161/01.CIR.0000074205.17807.D0

To investigate early events possibly related to the development of diabetic angiopathy, we examined whether 8-iso-prostaglandin F2alpha (8-iso-PGF2alpha) formation, a marker of in vivo oxidant stress, is altered in different stages of type 1 diabetes (T1DM) and whether it correlates with the rate of thromboxane (TX) A2 biosynthesis, a marker of in vivo platelet activation. We also investigated the relationship between inflammatory markers and F2-isoprostane formation in this setting. A cross-sectional study was performed in 23 insulin-treated patients aged