Nephropathic complication of type-2 diabetes is following pattern of autoimmune diseases?

• Published in: Diabetes research and clinical practice 2010-01, Vol.87 (1), p.33-37
• Main Authors: Arababadi, Mohammad Kazemi, Nosratabadi, Reza, Hassanshahi, Gholamhossein, Yaghini, Narges, Pooladvand, Vahid, Shamsizadeh, Ali, Hakimi, Hamid, Derakhshan, Reza
• Format: Article
• Language: English
• Subjects: Adult; Autoimmune Diseases - complications; Autoimmune Diseases - physiopathology; Diabetes; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - immunology; Diabetes Mellitus, Type 2 - physiopathology; Diabetic Nephropathies - blood; Diabetic Nephropathies - complications; Diabetic Nephropathies - physiopathology; Endocrinology & Metabolism; Environment; Enzyme-Linked Immunosorbent Assay; Female; Humans; IFN-γ; IL-17A; Interferon-gamma - blood; Interleukin-17 - blood; Iran; Male; Middle Aged; Nephropathy; Reference Values
• ISSN: 0168-8227; 1872-8227
• DOI: 10.1016/j.diabres.2009.09.027

Abstract The impact of several environmental and genetic factors on diabetes and its complications is well documented. The present study was aimed to examine the serum levels of IL-17A and IFN-γ as antagonistic cytokines in nephropathic and non-nephropathic type-2 diabetic patients. In this experimental study, serum samples were obtained from 180 type-2 diabetic patients, 100 nephropathic type-2 diabetic patients and 100 healthy controls. Serum levels of IL-17A and IFN-γ was detected by ELISA. Results of this study showed that the serum level of IFN-γ was higher in both diabetic patients (nephropathic and non-nephropathic) in comparison to the controls. In terms of IL-17A, while non-nephropathic type-2 diabetic patients showed an increased serum level of it, the other patients group had a lower serum level. Based on these findings, it can be concluded that the lower serum level of IL-17A is possibly associated with nephropathic complications of type-2 diabetes.