Sequential bone healing of immediately loaded mini-implants: histomorphometric and fluorescence analysis

Introduction Mini-implants are often immediately loaded for orthodontic treatment; however, changes in interfacial tissues caused by early loading and its effects might compromise the mini-implant's function. The purpose of this study was to compare the healing of interfacial tissues 1, 4, and...

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Published in:American journal of orthodontics and dentofacial orthopedics 2010, Vol.137 (1), p.80-90
Main Authors: Serra, Glaucio, Morais, Liliane S, Elias, Carlos Nelson, Meyers, Marc A, Andrade, Leonardo, Müller, Carlos A, Müller, Marcelo
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Calcification, Physiologic - physiology
Dental Alloys
Dental Implants
Dental Stress Analysis
Dentistry
Fluorescent Dyes
Implants, Experimental
Male
Medical sciences
Miniaturization
Orthodontic Anchorage Procedures - instrumentation
Orthodontic Appliances
Osseointegration - physiology
Otorhinolaryngology. Stomatology
Rabbits
Tibia - surgery
Titanium
Wound Healing - physiology
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Summary:Introduction Mini-implants are often immediately loaded for orthodontic treatment; however, changes in interfacial tissues caused by early loading and its effects might compromise the mini-implant's function. The purpose of this study was to compare the healing of interfacial tissues 1, 4, and 12 weeks after the placement of titanium-alloy mini-implants in New Zealand rabbits; some of the implants were loaded immediately and others were left unloaded. Methods Eighteen animals were used in the experiment. Each received 4 titanium grade 5 mini-implants (2.0 × 6.0 mm), 2 of which were immediately loaded with 1 N of force. Tissue healing was verified at 1, 4, and 12 weeks after placement. Four different fluorescent molecules were injected into the rabbits to label calcium deposition. After the rabbits were killed, mineralized bone samples with the mini-implants were removed, fixed, cut, stained, and observed with bright-field, polarized, and fluorescence microscopy. Results After 12 weeks of healing, higher bone contact and bone area were observed than after 1 or 4 weeks, regardless of loading. Differences between the loaded and unloaded groups were not observed ( P  
ISSN:0889-5406
1097-6752
DOI:10.1016/j.ajodo.2007.12.035