Estrogen Receptors and Cell Proliferation in Breast Cancer

Most of the actions of estrogens on the normal and abnormal mammary cells are mediated via estrogen receptors (ERs), including control of cell proliferation; however, there are also alternative pathways of estrogen action not involving ERs. Estrogens control several genes and proteins that induce th...

Full description

Saved in:
Bibliographic Details
Published in:Trends in endocrinology and metabolism 1997-10, Vol.8 (8), p.313-321
Main Authors: Ciocca, Daniel R, Fanelli, Mariel A
Format: Article
Language:English
Subjects:
Biological and medical sciences
Gynecology. Andrology. Obstetrics
Mammary gland diseases
Medical sciences
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Most of the actions of estrogens on the normal and abnormal mammary cells are mediated via estrogen receptors (ERs), including control of cell proliferation; however, there are also alternative pathways of estrogen action not involving ERs. Estrogens control several genes and proteins that induce the cells to enter the cell cycle (protooncogenes, growth factors); estrogens also act on proteins directly involved in the control of the cell cycle (cyclins), and moreover, estrogens stimulate the response of negative cell cycle regulators (p53, BRCA1). The next challenge for researchers is elucidating the integration of the interrelationships of the complex pathways involved in the control of cell proliferation. This brief review focuses on the mechanisms of estrogen action to control cell proliferation and the clinical implications in breast cancer. (Trends Endocrinol Metab 1997;8:313–321). © 1997, Elsevier Science Inc.
ISSN:1043-2760
1879-3061
DOI:10.1016/S1043-2760(97)00122-7