Molecular Properties of the CRF Receptor

Research into the biology of corticotropin-releasing factor (CRF) has been intensified significantly by the structural characterization of the CRF receptor (CRF-R). Two receptor subtypes, CRF-R1 and CRF-R2, and three functional splice variants of CRF-R2 have been discovered. It appears that ligand b...

Full description

Saved in:
Bibliographic Details
Published in:Trends in endocrinology and metabolism 1998-05, Vol.9 (4), p.140-145
Main Authors: Spiess, Joachim, Dautzenberg, Frank M, Sydow, Sabine, Hauger, Richard L, Rühmann, Andreas, Blank, Thomas, Radulovic, Jelena
Format: Article
Language:English
Subjects:
Biological and medical sciences
CRF
CRF binding
CRF ligand specificity
CRF receptor
CRF receptor desensitization
CRF receptor evolution
Fundamental and applied biological sciences. Psychology
Hormones and neuropeptides. Regulation
Hypothalamus. Hypophysis. Epiphysis. Urophysis
urocortin
Vertebrates: endocrinology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Research into the biology of corticotropin-releasing factor (CRF) has been intensified significantly by the structural characterization of the CRF receptor (CRF-R). Two receptor subtypes, CRF-R1 and CRF-R2, and three functional splice variants of CRF-R2 have been discovered. It appears that ligand binding requires interaction of the N-terminal domain with one or two other extracellular domains of the CRF-R. In contrast to the mammalian CRF-R1, the frog CRF-R1 discriminates between naturally occurring CRF-like peptides.
ISSN:1043-2760
1879-3061
DOI:10.1016/S1043-2760(98)00037-X