Application of fed-batch culture to citric acid production by Aspergillus niger: The effects of dilution rate and dissolved oxygen tension

Studies in conventional batch culture confirmed that the maximum citric acid production rate occurred prior to exhaustion of the growth‐limiting nutrient, i.e., when the growth rate was nonzero. The effects of dilution rate and the culture dissolved oxygen tension (DOT) were studied in chemostat cul...

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Bibliographic Details
Published in:Biotechnology and bioengineering 1988-07, Vol.32 (2), p.220-226
Main Authors: Dawson, M. W., Maddox, I. S., Boag, I. F., Brooks, J. D.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biotechnology
Fundamental and applied biological sciences. Psychology
Industrial applications and implications. Economical aspects
Methods. Procedures. Technologies
Microbial engineering. Fermentation and microbial culture technology
Other applications
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Summary:Studies in conventional batch culture confirmed that the maximum citric acid production rate occurred prior to exhaustion of the growth‐limiting nutrient, i.e., when the growth rate was nonzero. The effects of dilution rate and the culture dissolved oxygen tension (DOT) were studied in chemostat culture. Maximum citric acid yield and production rate were observed at low dilution rate (0.017 h−1) and high DOT value (90% of saturation). These findings were applied to a nitrogen‐limited fed batch culture, and allowed a productivity increase of 100% when compared with conventional batch culture.
ISSN:0006-3592
1097-0290
DOI:10.1002/bit.260320212