Plasma ACE2 Activity is an Independent Prognostic Marker in Chagas' Disease and Equally Potent as BNP

• Published in: Journal of cardiac failure 2010-02, Vol.16 (2), p.157-163
• Main Authors: Wang, Yong, PhD, Moreira, Maria da Consolação V., MD, PhD, Heringer-Walther, Silvia, MD, PhD, Ebermann, Linda, MSc, Schultheiss, Heinz-Peter, MD, Wessel, Niels, PhD, Siems, Wolf-Eberhard, PhD, Walther, Thomas, PhD
• Format: Article
• Language: English
• Subjects: Angiotensin-converting enzyme 2; B-type natriuretic peptide; Biomarkers - blood; Cardiovascular; Chagas Disease - blood; Chagas Disease - diagnosis; Chagas Disease - enzymology; Chagas Disease - mortality; Chagas' disease; Cohort Studies; Enzyme Activation - physiology; Female; Follow-Up Studies; Humans; Male; Middle Aged; Natriuretic Peptide, Brain - blood; Peptidyl-Dipeptidase A - blood; Predictive Value of Tests; Prognosis; Prospective Studies
• ISSN: 1071-9164; 1532-8414
• DOI: 10.1016/j.cardfail.2009.09.005

Abstract Background Angiotensin-converting enzyme (ACE) 2 is a novel homologue of ACE. It metabolizes angiotensin (Ang)II to Ang-(1-7). This study aims to investigate the diagnostic and prognostic potency of circulating ACE2 activity in patients with heart failure (HF) from Chagas' disease (CD). Methods and Results Blood samples were obtained from 111 CD patients and 40 age- and gender-matched healthy subjects. The CD patients were further subdivided according to their New York Heart Association classification. ACE2 activity was significantly increased in CD patients with HF, but not in patients without systolic dysfunction. Moreover, plasma ACE2 activity was significantly correlated with their clinical severity and echocardiographic parameters. Importantly, the potency of circulating ACE2 activity in CD patients was equally potent as that of B-type natriuretic peptide to predict cardiac death and heart transplant. Most importantly, patients with both parameters elevated were on a 5-fold higher risk to reach an endpoint than patients with increase in only 1 of the 2 parameters. Conclusions Determination of ACE2 activity may provide a new and important diagnostic and prognostic marker for patients with CD. ACE2 activity and BNP concentration have additive predictive value and may be used in combination to offer a new dimension of prediction in HF.