Increased Penicillin Nonsusceptibility of Nonvaccine-Serotype Invasive Pneumococci Other than Serotypes 19A and 6A in Post-7-Valent Conjugate Vaccine Era

According to population-based invasive pneumococcal surveillance in the United States during 2007, 898 (26%) of 3,511 isolates were penicillin nonsusceptible. Non-7-valent pneumococcal conjugate vaccine (PCV7) serotypes other than 19A accounted for 40% of these penicillin-nonsusceptible isolates; of...

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Bibliographic Details
Published in:The Journal of infectious diseases 2010-03, Vol.201 (5), p.770-775
Main Authors: Gertz, Robert E., Li, Zhongya, Pimenta, Fabiana C., Jackson, Delois, Juni, Billie A., Lynfield, Ruth, Jorgensen, James H., da Gloria Carvalho, Maria, Beall, Bernard W.
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Antibiotics
Applied microbiology
BACTERIA
Bacterial Typing Techniques
Bacteriology
Biological and medical sciences
Child
Child, Preschool
Cluster Analysis
Conjugate vaccines
DNA Fingerprinting
Epidemiology
Female
Fundamental and applied biological sciences. Psychology
Genotype
Heptavalent Pneumococcal Conjugate Vaccine
Humans
Infant
Infant, Newborn
Infections
Infectious diseases
Male
Medical sciences
Microbiology
Miscellaneous
Penicillin
Penicillin Resistance
Penicillins - pharmacology
Pneumococcal Infections - microbiology
Pneumococcal Vaccines - immunology
Prevalence
Preventive medicine
Respiratory diseases
Sequence Analysis, DNA
Serotyping
Streptococcus pneumoniae
Streptococcus pneumoniae - classification
Streptococcus pneumoniae - drug effects
Streptococcus pneumoniae - isolation & purification
Surveillance
United States - epidemiology
Vaccination
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
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Summary:According to population-based invasive pneumococcal surveillance in the United States during 2007, 898 (26%) of 3,511 isolates were penicillin nonsusceptible. Non-7-valent pneumococcal conjugate vaccine (PCV7) serotypes other than 19A accounted for 40% of these penicillin-nonsusceptible isolates; of these, serotypes 15A (11%), 23A (8%), 35B (8%), and 6C (5%) were most common (cumulatively 32% of penicillin-nonsusceptible isolates). Each except 6C represented a single serotype and clonal complex combination that predated the introduction of PCV7. We evaluated the genetic characteristics and nonsusceptibility to penicillin of non-PCV7 serotypes, and we found increased proportions of specific penicillin-nonsusceptible clones in serotypes 15A, 23A, 35B, and 6C, which potentially indicates a basic change of population structure within these individual serotypes.
ISSN:0022-1899
1573-6613
1537-6613
DOI:10.1086/650496