Monoamine levels in rat striatum after acute intraperitoneal injection of strictosidinic acid isolated from Psychotria myriantha Mull. Arg. (Rubiaceae)

Strictosidinic acid 10 mg/kg, isolated from Psychotria myriantha leaves, were administered intraperitoneally to Wistar male rats (n=5-6). After 60 minutes, striatum was dissected, homogenized and injected onto HPLC-ED chromatographic system. It was observed a 28.7% reduction in the 5-HT levels follo...

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Bibliographic Details
Published in:Phytomedicine (Stuttgart) 2010-03, Vol.17 (3), p.289-291
Main Authors: Farias, F.M., Passos, C.S., Arbo, M.D., Zuanazzi, J.A.S., Steffen, V.M., Henriques, A.T.
Format: Article
Language:English
Subjects:
3,4-Dihydroxyphenylacetic Acid - metabolism
Alkaloids
Animals
Carbolines - isolation & purification
Carbolines - pharmacology
Corpus Striatum - drug effects
Corpus Striatum - metabolism
Dopamine - metabolism
Glycosides - isolation & purification
Glycosides - pharmacology
Health aspects
Homovanillic Acid - metabolism
Injections, Intraperitoneal
Male
Metabolites
Migraine
Monoamine levels
Neurotransmitter Agents - administration & dosage
Neurotransmitter Agents - isolation & purification
Neurotransmitter Agents - pharmacology
Phenylacetates - metabolism
Plant Extracts - administration & dosage
Plant Extracts - chemistry
Plant Extracts - pharmacology
Plant Leaves
Psychotria myriantha
Rats
Rats, Wistar
Rubiaceae - chemistry
Serotonin - analogs & derivatives
Serotonin - metabolism
Striatum
Strictosidinic acid
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Summary:Strictosidinic acid 10 mg/kg, isolated from Psychotria myriantha leaves, were administered intraperitoneally to Wistar male rats (n=5-6). After 60 minutes, striatum was dissected, homogenized and injected onto HPLC-ED chromatographic system. It was observed a 28.7% reduction in the 5-HT levels followed up by an increase of 5-HIAA levels (29.4%). Furthermore there was a decrease of 8.0% in DA levels and an increase in the levels of metabolites DOPAC (21.5%) and HVA (52.5%). The results indicate that strictosidinic acid has a promising effect in the central nervous system, justifying more studies about the central actions of Psychotria compounds.
ISSN:0944-7113
1618-095X
DOI:10.1016/j.phymed.2009.05.008