Effect of weight loss on bone metabolism: comparison of vertical banded gastroplasty and medical intervention

We studied the effects of weight loss on bone metabolism. 16 consecutive surgically-treated (14 female, 2 male) morbidly obese patients and 65 obese (53 male, 12 female) medically-treated patients were enrolled in an observational study. Surgical treatment for morbidly obese patients was vertical ba...

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Bibliographic Details
Published in:Obesity surgery 2003-06, Vol.13 (3), p.383-388
Main Authors: Guney, Engin, Kisakol, Gurcan, Ozgen, Gokhan, Yilmaz, Candeger, Yilmaz, Rasih, Kabalak, Taylan
Format: Article
Language:English
Subjects:
Absorptiometry, Photon
Adult
Appetite Depressants - therapeutic use
Body Mass Index
Bone and Bones - metabolism
Bone density
Bone Density - physiology
Bones
Cohort Studies
Diet, Fat-Restricted
Female
Follow-Up Studies
Gastroplasty - methods
Humans
Male
Middle Aged
Multivariate Analysis
Obesity, Morbid - drug therapy
Obesity, Morbid - surgery
Older people
Osteoporosis
Probability
Prospective Studies
Treatment Outcome
Weight Loss
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Summary:We studied the effects of weight loss on bone metabolism. 16 consecutive surgically-treated (14 female, 2 male) morbidly obese patients and 65 obese (53 male, 12 female) medically-treated patients were enrolled in an observational study. Surgical treatment for morbidly obese patients was vertical banded gastroplasty (VBG). Studies were performed prior to and 12 months after the start of treatment. Bone mineral density (BMD), bone turnover markers, sex steroids, calcium excretion and parathyroid hormone measurements were done at each visit. Weight loss was more prominent with surgical than with medical treatments. Bone loss was also pronounced in the surgical treatment group, and occurred at the hip level only (P
ISSN:0960-8923
1708-0428
DOI:10.1381/096089203765887705