Antifungal activity of the methanolic extract and alkaloids of Glaucium oxylobum

The methanolic extract and total alkaloids of the aerial parts of Glaucium oxylobum exhibited good activity against Microsporum gypseum, Microsporum canis, Trichophyton mentagrophytes and Epidermophyton floccosum. Four alkaloids, dicentrine, glaucine, protopine, and α-allocryptopine, were identified...

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Bibliographic Details
Published in:Fitoterapia 2003-07, Vol.74 (5), p.493-496
Main Authors: Morteza-Semnani, K., Amin, Gh, Shidfar, M.R., Hadizadeh, H., Shafiee, A.
Format: Article
Language:English
Subjects:
Alkaloids
Alkaloids - administration & dosage
Alkaloids - pharmacology
Alkaloids - therapeutic use
Antifungal activity
Antifungal Agents - administration & dosage
Antifungal Agents - pharmacology
Antifungal Agents - therapeutic use
Biological and medical sciences
Dose-Response Relationship, Drug
General pharmacology
Glaucium oxylobum
Humans
Medical sciences
Microbial Sensitivity Tests
Mitosporic Fungi - drug effects
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Phytotherapy
Plant Extracts - administration & dosage
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Plant Preparations
Ranunculaceae
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Summary:The methanolic extract and total alkaloids of the aerial parts of Glaucium oxylobum exhibited good activity against Microsporum gypseum, Microsporum canis, Trichophyton mentagrophytes and Epidermophyton floccosum. Four alkaloids, dicentrine, glaucine, protopine, and α-allocryptopine, were identified as the compounds responsible for the antifungal activity of this plant.
ISSN:0367-326X
DOI:10.1016/S0367-326X(03)00113-8