Growth-hormone response to combined stimulation with GHRH plus GH-releasing peptide-6 in obese patients with polycystic ovary syndrome before and after short-term fasting

Controversial data were reported on GH response to different provocative stimuli in obese patients with polycystic ovary syndrome (PCOS). The objective of our study was to assess the effect of short-term fasting on GH response to combined stimulus with GHRH+GH-releasing peptide-6 (GHRP-6) in obese p...

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Bibliographic Details
Published in:Journal of endocrinological investigation 2003-04, Vol.26 (4), p.333-340
Main Authors: MICIC, D, SUMARAC-DUMANOVIC, M, MACUT, Dj, KENDERESKI, A, ZORIC, S, POPOVI'C, V, CVIJOVIC, G, DIEGUEZ, C, CASANUEVA, F. F
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Fasting - blood
Female
Female genital diseases
Growth Hormone-Releasing Hormone - administration & dosage
Growth Hormone-Releasing Hormone - physiology
Gynecology. Andrology. Obstetrics
Human Growth Hormone - administration & dosage
Human Growth Hormone - blood
Humans
Insulin - blood
Insulin-Like Growth Factor I - metabolism
Leptin - blood
Medical sciences
Metabolic diseases
Non tumoral diseases
Obesity
Obesity - blood
Obesity - complications
Oligopeptides - physiology
Polycystic Ovary Syndrome - blood
Polycystic Ovary Syndrome - complications
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Summary:Controversial data were reported on GH response to different provocative stimuli in obese patients with polycystic ovary syndrome (PCOS). The objective of our study was to assess the effect of short-term fasting on GH response to combined stimulus with GHRH+GH-releasing peptide-6 (GHRP-6) in obese patients with PCOS and possible relation with leptin and insulin changes during fasting. Twelve obese PCOS women and nine obese control women participated in 3-day fasting. GH response, IGF-I, insulin and leptin were measured after GHRH+ GHRP-6, before and after short-term fasting. Obese PCOS patients had significantly greater GH peak after GHRH+GHRP-6 before fasting. Enhanced response to GH stimulation was found after fasting without substantial differences between obese PCOS and obese controls. Insulin and leptin significantly decreased, while insulin sensitivity significantly improved in both groups during fasting. In conclusion, obese PCOS patients have peculiar type of GH response to GHRH+GHRP-6 before fasting, possibly due to enhanced sensitivity of somatotrophs. Observed changes in insulin and leptin may participate in modulation of enhanced GH response after short-term fasting to GHRH+GHRP-6 in PCOS and obese controls.
ISSN:0391-4097
1720-8386
DOI:10.1007/BF03345181