A preliminary assessment of macular function by MF-ERG in myopic eyes with CNV with complete response to photodynamic therapy

To evaluate by multifocal electroretinogram (MF-ERG) macular function before and after photodynamic therapy (PDT) in myopic eyes with choroidal neovascularization (CNV). Ten eyes with classic subfoveal CNV due to pathologic myopia were studied with MF-ERG before and after PDT in order to evaluate th...

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Bibliographic Details
Published in:European journal of ophthalmology 2003-06, Vol.13 (5), p.461-467
Main Authors: MOSCHOS, M. N, PANAYOTIDIS, D, MOSCHOS, M. M, BOUROS, Chr, THEODOSSIADIS, P. G, THEODOSSIADIS, G. P
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Choroidal Neovascularization - drug therapy
Choroidal Neovascularization - etiology
Coloring Agents
Electroretinography
Female
Fluorescein Angiography
Follow-Up Studies
Humans
Indocyanine Green
Male
Medical sciences
Middle Aged
Myopia - complications
Ophthalmology
Photochemotherapy
Photosensitizing Agents - therapeutic use
Porphyrins - therapeutic use
Prognosis
Retina - physiology
Vision disorders
Visual Acuity
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Summary:To evaluate by multifocal electroretinogram (MF-ERG) macular function before and after photodynamic therapy (PDT) in myopic eyes with choroidal neovascularization (CNV). Ten eyes with classic subfoveal CNV due to pathologic myopia were studied with MF-ERG before and after PDT in order to evaluate the results of PDT with verteporfin. The post-treatment follow-up was 6 months. Visual acuity testing, ophthalmic examinations, fluorescein and indocyanine green angiograms, and MF-ERG recordings were used to evaluate the results of PDT with verteporfin. The post-treatment period was 6 months. Before treatment, the electrical response densities in the foveal and perifoveal areas were apparently decreased in all patients. Six months after treatment, the mean retinal response densities in the same areas were found to be higher than before treatment. MF-ERG evaluates objectively the macular function in myopic eyes with CNV. After successful PDT, the electrical activity of the foveal and parafoveal areas is higher than before treatment. This finding postulates the efficacy of PDT in the treatment of CNV.
ISSN:1120-6721
1724-6016
DOI:10.1177/112067210301300507