Family-based association study of markers on chromosome 22 in schizophrenia using African-American, European-American, and Chinese families

Several studies suggest that loci at chromosome 22q11.2‐q13 might be linked to susceptibility to schizophrenia. Here we performed family‐based association studies on chromosome 22q using 12 DNA microsatellite markers in African‐American, European‐American, and Chinese pedigrees. The marker D22S683 s...

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Bibliographic Details
Published in:American journal of medical genetics. Part B, Neuropsychiatric genetics Neuropsychiatric genetics, 2003-07, Vol.120B (1), p.11-17
Main Authors: Takahashi, Sakae, Cui, Yu-hu, Kojima, Takuya, Han, Yong-hua, Zhou, Ru-lum, Kamioka, Masashi, Yu, Shun-ying, Matsuura, Masato, Matsushima, Eisuyke, Wilcox, Marsha, Arinami, Tadao, Shen, Yu-cun, Faraone, Stephen V., Tsuang, Ming T.
Format: Article
Language:English
Subjects:
Adult
Asian People - genetics
Black or African American
Black People - ethnology
Black People - genetics
chromosome 22
Chromosome Mapping
Chromosomes, Human, Pair 22 - genetics
D22S683
family-based association study
FBAT
Female
Genetic Linkage
Genetic Markers
Genotype
Humans
Male
Microsatellite Repeats
Middle Aged
Nuclear Family
Pedigree
schizophrenia
Schizophrenia - genetics
White People - ethnology
White People - genetics
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Summary:Several studies suggest that loci at chromosome 22q11.2‐q13 might be linked to susceptibility to schizophrenia. Here we performed family‐based association studies on chromosome 22q using 12 DNA microsatellite markers in African‐American, European‐American, and Chinese pedigrees. The marker D22S683 showed significant linkage and association with schizophrenia in not only the European‐American sample but also in a combined sample (European‐American and Chinese samples). Notably, D22S683 is located nearby and between D22S278 and D22S283, which have shown linkage and association to schizophrenia in prior reports. However, we found no significant association for the African‐American sample. In conclusion, our data provide further support for the idea that the region around D22S683 contains a susceptibility gene for schizophrenia. © 2003 Wiley‐Liss, Inc.
ISSN:1552-4841
1552-485X
DOI:10.1002/ajmg.b.20031