Exercise-induced cholesterol depletion and Na+,K(+)-ATPase activities in human red cell membrane

Red cell membranes were isolated from blood samples obtained from athletes during exhaustive exercise on a bicycle ergometer and during the subsequent recovery period of 60 min. Plasma lactate levels were also determined. During exercise, cell membranes were progressively depleted of cholesterol and...

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Bibliographic Details
Published in:Experimental physiology 1992-11, Vol.77 (6), p.933-936
Main Authors: Shanmugasundaram, KR, Padmavathi, C, Acharya, S, Vidhyalakshmi, N, Vijayan, VK
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Cholesterol - blood
Cholesterol - deficiency
Erythrocyte Membrane - metabolism
Exercise Test
Fundamental and applied biological sciences. Psychology
Humans
Lactates - blood
Lactic Acid
Male
Phospholipids - blood
Physical Exertion
Sodium-Potassium-Exchanging ATPase - blood
Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports
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Summary:Red cell membranes were isolated from blood samples obtained from athletes during exhaustive exercise on a bicycle ergometer and during the subsequent recovery period of 60 min. Plasma lactate levels were also determined. During exercise, cell membranes were progressively depleted of cholesterol and, at exhaustion, membrane cholesterol was less than 80% of the initial level. A parallel decline in Na+,K(+)-ATPase was also noted, while phospholipid reduction was around 5%. During recovery, the erythrocyte membrane cholesterol and Na+,K(+)-ATPase increased, but at a slow rate and were inversely proportional to plasma lactate content.
ISSN:0958-0670
1469-445X
DOI:10.1113/expphysiol.1992.sp003663