Elaboration of laboratory strains of Ebola virus and study of pathophysiological reactions of animals inoculated with these strains

Selective passages in animals and cell cultures were used to produce a set of Ebola virus (EBO) laboratory strains with changed virulence for some animal genera. Comparative study of the genomes of wild-type EBO and selected variants formed the basis for studying the molecular causes of EBO virulenc...

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Bibliographic Details
Published in:Acta tropica 2003-08, Vol.87 (3), p.321-329
Main Authors: Chepurnov, A.A., Zubavichene, N.M., Dadaeva, A.A.
Format: Article
Language:English
Subjects:
Adaptation
Animals
Cercopithecus aethiops
Ebola virus
Ebolavirus - genetics
Ebolavirus - pathogenicity
Genetic Variation
Genome, Viral
Guinea Pigs
Hemorrhagic Fever, Ebola - physiopathology
Hemorrhagic Fever, Ebola - virology
Mice
Mice, Inbred ICR
Pathogenesis
Rabbits
Variants
Vero Cells
Virulence - genetics
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Summary:Selective passages in animals and cell cultures were used to produce a set of Ebola virus (EBO) laboratory strains with changed virulence for some animal genera. Comparative study of the genomes of wild-type EBO and selected variants formed the basis for studying the molecular causes of EBO virulence. Investigation of pathophysiological reactions of the animals inoculated with these strains allowed some key factors in Ebola fever pathogenesis to be determined.
ISSN:0001-706X
1873-6254
DOI:10.1016/S0001-706X(03)00122-0