The diagnostic value of salivary fluid levels of beta 2-microglobulin, lysozyme and lactoferrin for primary Sjögren's syndrome

In search of a simple non-invasive diagnostic test for primary Sjögren's syndrome (SS) the concentration of beta 2-microglobulin (beta 2-m), lysozyme (LZM) and lactoferrin (Lf) was measured in stimulated parotid saliva of 39 patients with primary SS, 42 patients suspected of the syndrome in who...

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Bibliographic Details
Published in:Clinical rheumatology 1992-12, Vol.11 (4), p.521-525
Main Authors: Markusse, H M, Otten, H G, Vroom, T M, Smeets, T J, Fokkens, N, Breedveld, F C
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
beta 2-Microglobulin - metabolism
Female
Humans
Lactoferrin - blood
Lactoferrin - metabolism
Male
Middle Aged
Muramidase - blood
Muramidase - metabolism
Osmolar Concentration
Reference Values
Saliva - metabolism
Sjogren's Syndrome - blood
Sjogren's Syndrome - diagnosis
Sjogren's Syndrome - metabolism
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Summary:In search of a simple non-invasive diagnostic test for primary Sjögren's syndrome (SS) the concentration of beta 2-microglobulin (beta 2-m), lysozyme (LZM) and lactoferrin (Lf) was measured in stimulated parotid saliva of 39 patients with primary SS, 42 patients suspected of the syndrome in whom the diagnosis could be excluded (NON-SS) and in 41 normal control individuals. Salivary fluid levels of beta 2-m, LZM and Lf exceeding the mean + 2 x standard deviation of healthy control values were found in respectively 58%, 23%, and 26% of the primary SS patients and in 7%, 11% and 0% of the NON-SS patients. The results of this study indicate that due to the low sensitivity the tests are not suitable as a screening procedure for patients suspected of having primary SS. However, measurement of beta 2-m in stimulated parotid saliva may be used as an adjunctive diagnostic test for primary SS.
ISSN:0770-3198
DOI:10.1007/BF02283111