Markers informative for ancestry demonstrate consistent megabase-length linkage disequilibrium in the African American population

Admixture mapping is a potentially powerful tool for mapping complex genetic diseases. For application of this method, admixed individuals must have genomes composed of large segments derived intact from each founding population. Such segments are thought to be present in African Americans (AA) and...

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Bibliographic Details
Published in:Human genetics 2003-08, Vol.113 (3), p.211-219
Main Authors: COLLINS-SCHRAMM, Heather E, CHIMA, Bill, OPERARIO, Darwin J, CRISWELL, Lindsey A, SELDIN, Michael F
Format: Article
Language:English
Subjects:
African Americans
African Continental Ancestry Group - genetics
Analysis
Biological and medical sciences
Chromosomes, Human, Pair 5 - genetics
Consortia
Disease
European Continental Ancestry Group - genetics
Founder Effect
Fundamental and applied biological sciences. Psychology
Genealogy
Genetic Markers
Genetic Variation
Genetics of eukaryotes. Biological and molecular evolution
Genetics, Population
Genome, Human
Genomics
Human
Humans
Linkage Disequilibrium
Mutation
Population
Population genetics, reproduction patterns
Type 2 diabetes
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Summary:Admixture mapping is a potentially powerful tool for mapping complex genetic diseases. For application of this method, admixed individuals must have genomes composed of large segments derived intact from each founding population. Such segments are thought to be present in African Americans (AA) and should be demonstrable by examination of linkage disequilibrium (LD). Previous studies using a variety of polymorphic markers have variably reported long-range LD or rapid decay of LD. To further define the extent and characteristics of LD caused by admixture in the AA population, the current study utilized a set of 52 diallelic markers that were selected for large standard variances between putative representatives of the founder populations. LD was examined in over 250 marker-pairs, including linked markers from four different chromosomal regions and an equal number of matched unlinked comparisons. In the representative founder populations, strong LD was not observed for markers separated by more than 10 kb. In contrast, results indicated significant LD ( P
ISSN:0340-6717
1432-1203
DOI:10.1007/s00439-003-0961-1