Physiological and pathological relevance of extracellular NM23/NDP kinases

The NM23 gene is overexpressed in many hematological malignancies and other neoplasms. Some tumor cell lines that overexpress NM23 secrete this protein into extracellular environment. In this study, we found that the serum concentration of NM23-H1 protein was significantly higher in patients with va...

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Bibliographic Details
Published in:Journal of bioenergetics and biomembranes 2003-02, Vol.35 (1), p.89-93
Main Authors: Okabe-Kado, Junko, Kasukabe, Takashi
Format: Article
Language:English
Subjects:
Animals
Biomarkers, Tumor - analysis
Biomarkers, Tumor - metabolism
Cell Division
Cell Line, Tumor - metabolism
Cell Survival
Extracellular Fluid - metabolism
Gene Expression Regulation, Enzymologic
Gene Expression Regulation, Neoplastic
Hematology
Humans
Kinases
Leukemia
Lymphoma
Neoplasms - blood
Neoplasms - diagnosis
Neoplasms - metabolism
Neoplasms - pathology
NM23 Nucleoside Diphosphate Kinases
Nucleoside-Diphosphate Kinase
Physiology
Predictive Value of Tests
Proteins - metabolism
Tumors
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Summary:The NM23 gene is overexpressed in many hematological malignancies and other neoplasms. Some tumor cell lines that overexpress NM23 secrete this protein into extracellular environment. In this study, we found that the serum concentration of NM23-H1 protein was significantly higher in patients with various hematological malignancies. The serum level of NM23-H1 protein was clinically useful as a prognostic factor in malignant lymphoma and acute myelogeneous leukemia (AML). The level of NM23-H1 protein in all of the normal serum samples examined was lower than 10 ng/mL, while those in the tumors varied from about 0 to 1000 ng/mL. Exogenously added NM23-H1 protein did not affect the growth or survival of various leukemia and lymphoma cell lines. However, NM23-H1 protein inhibited the survival of adherent normal peripheral blood mononuclear cells (PBMNC) at 100-1000 ng/mL, and slightly stimulated the survival of nonadherent PBMNC. These results suggest that the effect of NM23-H1 protein on normal PBMNC may be associated with a poor prognosis in hematological malignancies.
ISSN:0145-479X
1573-6881
DOI:10.1023/A:1023402125186