Temporal expression of immunoreactivity for heat shock protein 25 (Hsp25) in the rat periodontal ligament following transection of the inferior alveolar nerve

The present study examined the immunohistochemical localization of heat shock protein 25 (Hsp25) during the regeneration of nerve fibers and Schwann cells in the periodontal ligament of the rat lower incisor following transection of the inferior alveolar nerve. In the untreated control group, the pe...

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Bibliographic Details
Published in:Brain research 2003-07, Vol.979 (1), p.146-152
Main Authors: Iijima, Kenji, Harada, Fumiko, Hanada, Kooji, Nozawa-Inoue, Kayoko, Aita, Megumi, Atsumi, Yukako, Wakisaka, Satoshi, Maeda, Takeyasu
Format: Article
Language:English
Subjects:
Animals
Axotomy
Biological and medical sciences
Development. Senescence. Regeneration. Transplantation
Fundamental and applied biological sciences. Psychology
Heat-Shock Proteins - metabolism
Hsp25
Hsp25 protein
Immunohistochemistry
inferior alveolar nerve
Mandibular Nerve - surgery
Nerve Regeneration - physiology
Periodontal ligament
Periodontal Ligament - innervation
Periodontal Ligament - metabolism
Rats
Rats, Wistar
Regeneration
Ruffini Ending
Schwann Cells - metabolism
Vertebrates: nervous system and sense organs
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Summary:The present study examined the immunohistochemical localization of heat shock protein 25 (Hsp25) during the regeneration of nerve fibers and Schwann cells in the periodontal ligament of the rat lower incisor following transection of the inferior alveolar nerve. In the untreated control group, the periodontal ligament of rat incisor did not contain any Hsp25-immunoreaction. On postoperative day 3 (PO 3d), a small number of Schwann cells with slender cytoplasmic processes exhibited Hsp25-immunoreactivity. From PO 5d to PO 21d, Hsp25-positive nerve fibers and Schwann cells drastically increased in number in the alveolar half of the ligament. Although the axons of some regenerating Ruffini-like endings also showed Hsp25-immunoreactions, the migrated Schwann cells were devoid of Hsp25-immunoreaction. Thereafter, Hsp25-positive structures decreased in number gradually to disappear from the periodontal ligament by PO 56d. This temporal expression of Hsp25 in the periodontal ligament well-reflected the regeneration process of the nerve fibers. Hsp25 in the regenerating nerve fibers and denervated Schwann cells most likely serves in modulating actin dynamics and as a cellular inhibitor of apoptosis, respectively.
ISSN:0006-8993
1872-6240
DOI:10.1016/S0006-8993(03)02889-0