Spinal muscular atrophy: MR evaluation

The neurogenic myopathy of spinal muscular atrophy (SMA) is degeneration of anterior horn cells of the spinal cord and associated muscle weakness. In three patients with the severe type, according to Dubowitz's classification, magnetic resonance imaging (MRI) of the lower extremity showed sever...

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Bibliographic Details
Published in:Pediatric radiology 1992-12, Vol.22 (8), p.584-586
Main Authors: LIU, G.-C, JONG, Y.-J, CHIANG, C.-H, YANG, C.-W
Format: Article
Language:English
Subjects:
Biological and medical sciences
Child
Child, Preschool
Female
Humans
Infant
Investigative techniques, diagnostic techniques (general aspects)
Magnetic Resonance Imaging
Male
Medical sciences
Muscular Atrophy, Spinal - pathology
Nervous system
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Spinal Muscular Atrophies of Childhood - pathology
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Summary:The neurogenic myopathy of spinal muscular atrophy (SMA) is degeneration of anterior horn cells of the spinal cord and associated muscle weakness. In three patients with the severe type, according to Dubowitz's classification, magnetic resonance imaging (MRI) of the lower extremity showed severe atrophy of the entire muscle bundles of the thigh and the calf. Nine intermediate type patients had ragged atrophy of muscle bundles of the thigh and the calf with selective preservation of adductor longus muscle. Five patients with the mild type had fatty infiltration of muscle bundles and increased intermuscular fat planes. MRI was insufficient for the evaluation of cervical cord abnormalities. MRI of the lower extremity was a reliable complementary modality for the diagnosis and follow-up of SMA patients.
ISSN:0301-0449
1432-1998
DOI:10.1007/BF02015357