Pneumococcal antigens and serum antibody responses in experimentally induced sinusitis

Maxillary sinusitis was induced in New Zealand White rabbits with Streptococcus pneumoniae serotype 3 and the serum antibody response was recorded by enzyme immunoassay. Activity of the three major immunoglobulin classes, viz. IgG, IgA and IgM, against the type-specific capsular polysaccharide, the...

Full description

Saved in:
Bibliographic Details
Published in:European archives of oto-rhino-laryngology 1992-12, Vol.249 (7), p.374-379
Main Authors: WESTRIN, K. M, FREIJD, A, STIERNA, P
Format: Article
Language:English
Subjects:
Animals
Antibodies, Bacterial - analysis
Antibodies, Bacterial - biosynthesis
Antigens, Bacterial - immunology
Bacterial Capsules - immunology
Biological and medical sciences
Immunoglobulin A - analysis
Immunoglobulin A - biosynthesis
Immunoglobulin G - analysis
Immunoglobulin G - biosynthesis
Immunoglobulin M - analysis
Immunoglobulin M - biosynthesis
Maxillary Sinusitis - microbiology
Maxillary Sinusitis - pathology
Medical sciences
Non tumoral diseases
Otorhinolaryngology. Stomatology
Pneumococcal Infections - immunology
Pneumococcal Infections - pathology
Polysaccharides, Bacterial - immunology
Rabbits
Streptococcus pneumoniae - immunology
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Maxillary sinusitis was induced in New Zealand White rabbits with Streptococcus pneumoniae serotype 3 and the serum antibody response was recorded by enzyme immunoassay. Activity of the three major immunoglobulin classes, viz. IgG, IgA and IgM, against the type-specific capsular polysaccharide, the cell wall C-polysaccharide as well as its subunit phosphorylcholine was analyzed. A pronounced increase in immunoglobulins reactive to the specific capsular antigen was observed throughout the study period, with the rise being particularly noticeable during the first 2 weeks. An increase in anti-C-polysaccharide antibodies was also evident, but no reaction to phosphorylcholine could be detected. Although the histological findings at 3 and 4 weeks varied in spite of similar serum antibody responses, a correlation appeared to exist between a more rapidly increasing anti-capsular IgG production and the prevalence of a purulent sinus secretion.
ISSN:0937-4477
1434-4726
DOI:10.1007/BF00192257