Effects of antiasthma drugs on the growth of Chlamydophila pneumoniae in HEp-2 cells

A possible link between Chlamydophila pneumoniae infection and adult-onset asthma has been raised recently. To obtain further insight into the association of C. pneumoniae with asthma, we assessed the effects of antiasthma drugs commonly used in Japan on the growth of C. pneumoniae in HEp-2 cells. T...

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Bibliographic Details
Published in:Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 2003-06, Vol.9 (2), p.160-164
Main Authors: Komura, Hayashi, Ouchi, Kazunobu, Matsushima, Hiroshi, Shirai, Mutsunori, Nakazawa, Teruko, Furukawa, Susumu
Format: Article
Language:English
Subjects:
Anti-Asthmatic Agents - pharmacology
Antiasthma drugs
Asthma
Biological and medical sciences
Cell Line
Chlamydophila pneumoniae
Chlamydophila pneumoniae - drug effects
Chlamydophila pneumoniae - growth & development
Glucocorticoids - pharmacology
Humans
Inhalant glucocorticoids
Medical sciences
Microbial Sensitivity Tests
Pharmacology. Drug treatments
Respiratory system
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Summary:A possible link between Chlamydophila pneumoniae infection and adult-onset asthma has been raised recently. To obtain further insight into the association of C. pneumoniae with asthma, we assessed the effects of antiasthma drugs commonly used in Japan on the growth of C. pneumoniae in HEp-2 cells. The growth was enhanced two times by inhalant glucocorticoids, such as fluticasone propionate and beclomethasone, as well as hydrocortisone succinate. Unexpectedly, two nonsteroidal antiasthma drugs, tranilast and seratrodast, an adenine nucleotidelowering agent and a thromboxane A2 receptor antagonist, respectively, were shown to inhibit chlamydial growth in vitro. The minimum inhibitory concentration and minimum chlamydicidal concentration were both 64μg/ml, which are comparable to the peak serum levels achievable by a therapeutic dosage. These results suggest that some antiasthma drugs may affect the therapeutic outcome of C. pneumoniae-associated bronchial asthma by their effects on C. pneumoniae.
ISSN:1341-321X
1437-7780
DOI:10.1007/s10156-003-0239-5