Age differences in allostatic load: an index of physiological dysregulation

This preliminary report examines variation in allostatic load by age for a large nationally representative population of the United States. It uses data on 13 indicators of physiologic dysregulation from a nationally representative sample of the US population 20 years of age and over. Allostatic loa...

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Bibliographic Details
Published in:Experimental gerontology 2003-07, Vol.38 (7), p.731-734
Main Authors: Crimmins, Eileen M., Johnston, Melanie, Hayward, Mark, Seeman, Teresa
Format: Article
Language:English
Subjects:
Adaptation, Physiological
Adult
Aging - physiology
Allostatic load
Biomarkers - blood
Body Mass Index
C-Reactive Protein - analysis
Creatinine - blood
Cross-Sectional Studies
Fibrinogen - analysis
Health Status Indicators
Health Surveys
Homocysteine - blood
Humans
Hypertension - physiopathology
Middle Aged
National Health and Nutrition Examination Survey
Peak Expiratory Flow Rate
Physiologic dysregulation
Risk Factors
Selection Bias
Serum Albumin - analysis
Stress, Physiological - physiopathology
United States
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Summary:This preliminary report examines variation in allostatic load by age for a large nationally representative population of the United States. It uses data on 13 indicators of physiologic dysregulation from a nationally representative sample of the US population 20 years of age and over. Allostatic load is remarkably constant in the older ages after increasing sharply in the years from 20 to 60. We hypothesize that this represents mortality selectivity of the population by physiological status.
ISSN:0531-5565
1873-6815
DOI:10.1016/S0531-5565(03)00099-8