Ventilatory responses preceding hypoxia-induced arousal in infants: effects of sleep-state

Augmented ventilation and/or arousal in response to hypoxia are important protective mechanisms during sleep. We aimed to quantify ventilatory responses preceding hypoxia-induced arousal in infants and determine the effects of sleep-state. Fifteen term infants were studied at 2–4 weeks, 2–3 and 5–6...

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Bibliographic Details
Published in:Respiratory physiology & neurobiology 2003-07, Vol.136 (2), p.235-247
Main Authors: Parslow, Peter M, Harding, Richard, Cranage, Susan M, Adamson, T.Michael, Horne, Rosemary S.C
Format: Article
Language:English
Subjects:
Aging
Arousal - physiology
Biological and medical sciences
Blood Gas Analysis - methods
Carbon Dioxide - metabolism
Development, infants
Electroencephalography
Female
Fundamental and applied biological sciences. Psychology
Humans
Hypoxia - physiopathology
Hypoxia, arousal, sleep states
Infant
Infant, Newborn
Male
Mammals, humans
Monitoring, Physiologic
Oxygen - physiology
Partial Pressure
Polysomnography - methods
Pulmonary Gas Exchange
Reaction Time
Respiration
Respiratory Mechanics - physiology
Sleep Stages - physiology
Sleep, arousal, hypoxia
Sleep. Vigilance
Vertebrates: nervous system and sense organs
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Summary:Augmented ventilation and/or arousal in response to hypoxia are important protective mechanisms during sleep. We aimed to quantify ventilatory responses preceding hypoxia-induced arousal in infants and determine the effects of sleep-state. Fifteen term infants were studied at 2–4 weeks, 2–3 and 5–6 months of age. Ventilatory responses to 15% oxygen inhalation were expressed as breath-by-breath changes from normoxic levels and averaged over 5, 10 and 15 breaths preceding arousal. Minute ventilation preceding arousal significantly increased above normoxic levels only in AS at 5–6 months. There were no sleep-state related differences in minute ventilation, oxygen saturation or carbon dioxide levels (expressed as changes from normoxic values) at 5, 10 or 15 breaths preceding arousal. However, the rate of oxygen desaturation during hypoxia in AS was two to four times faster than in QS at each age. We conclude that the ventilatory responses preceding hypoxia-induced arousal do not differ between sleep-states and that arousal occurs at similar levels of desaturation in both states.
ISSN:1569-9048
1878-1519
DOI:10.1016/S1569-9048(03)00085-5