Neural correlates of IgE-mediated food allergy

Although many authors have considered the possibility of a direct interaction between food allergy and behavioral changes, the evidence supporting this hypothesis is elusive. Here, we show that after oral ovalbumin (OVA) challenge, allergic mice present higher levels of anxiety, increased Fos expres...

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Bibliographic Details
Published in:Journal of neuroimmunology 2003-07, Vol.140 (1), p.69-77
Main Authors: Basso, Alexandre Salgado, Azevedo Costa Pinto, Frederico, Russo, Momtchilo, Giorgetti Britto, Luiz Roberto, de Sá-Rocha, Luiz Carlos, Palermo Neto, João
Format: Article
Language:English
Subjects:
Administration, Oral
Animals
Antibodies, Anti-Idiotypic - administration & dosage
Anxiety - immunology
Anxiety - physiopathology
Avoidance Learning - physiology
Brain Chemistry - immunology
c- fos
CNS
Emotionality
Emotions - physiology
Feeding Behavior - physiology
Food allergy
Food Hypersensitivity - immunology
Food Hypersensitivity - metabolism
Food Hypersensitivity - prevention & control
Food Hypersensitivity - psychology
IgE
Immunization
Immunoglobulin E - immunology
Immunoglobulin E - physiology
Injections, Intraperitoneal
Male
Mice
Mice, Inbred BALB C
Neurons - metabolism
Neurons - physiology
Ovalbumin - administration & dosage
Ovalbumin - immunology
Proto-Oncogene Proteins c-fos - biosynthesis
Psychological disorders
Psychoneuroimmunology
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Summary:Although many authors have considered the possibility of a direct interaction between food allergy and behavioral changes, the evidence supporting this hypothesis is elusive. Here, we show that after oral ovalbumin (OVA) challenge, allergic mice present higher levels of anxiety, increased Fos expression in emotionality-related brain areas, and aversion to OVA-containing solution. Moreover, treatment with anti-IgE antibody or induction of oral tolerance abrogate both food aversion and the expression of c- fos in the central nervous system (CNS). Our findings establish a direct relationship between brain function and food allergy, thus creating a solid ground for understanding the etiology of psychological disorders in allergic patients.
ISSN:0165-5728
1872-8421
DOI:10.1016/S0165-5728(03)00166-8