Acupuncture suppresses ischemia-induced increase in c-Fos expression and apoptosis in the hippocampal CA1 region in gerbils

Acupuncture has been used for the enhancement of functional recovery from various disorders including stroke. In the present study, the effects of acupuncture on the c-Fos expression and apoptosis in the hippocampal CA1 region of gerbils following transient global ischemia were investigated via immu...

Full description

Saved in:
Bibliographic Details
Published in:Neuroscience letters 2003-08, Vol.347 (1), p.5-8
Main Authors: Jang, Mi-Hyeon, Shin, Min-Chul, Lee, Taeck-Hyun, Lim, Baek-Vin, Shin, Mal-Soon, Min, Byung-Il, Kim, Hong, Cho, Sonhae, Kim, Ee-Hwa, Kim, Chang-Ju
Format: Article
Language:English
Subjects:
Acupuncture
Acupuncture Therapy
Animals
Apoptosis
Biological and medical sciences
Brain Ischemia - metabolism
Brain Ischemia - pathology
c-Fos
Caspase 3
Caspases - metabolism
Gerbillinae
Hippocampus - metabolism
Hippocampus - pathology
In Situ Nick-End Labeling
Ischemic gerbils
Male
Medical sciences
Miscellaneous
Proto-Oncogene Proteins c-fos - metabolism
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
Terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling staining
Zusanli acupoint
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Acupuncture has been used for the enhancement of functional recovery from various disorders including stroke. In the present study, the effects of acupuncture on the c-Fos expression and apoptosis in the hippocampal CA1 region of gerbils following transient global ischemia were investigated via immunohistochemistry for c-Fos and caspase-3 and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay. Enhanced Fos, TUNEL, and caspase-3 positivities were detected in the hippocampal CA1 region in the ischemic gerbils. Acupunctural treatment suppressed the ischemia-induced increment in the number of Fos-, TUNEL-, and caspase-3-positive cells: the most potent suppressive effect was observed at the Zusanli acupoint. These results suggest that acupunctural treatment alleviates ischemia-induced apoptosis and may aid in the recovery following ischemic cerebral injury.
ISSN:0304-3940
1872-7972
DOI:10.1016/S0304-3940(03)00512-3