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PNEUMOCANDINS FROM Zalerion arboricola: III. STRUCTURE ELUCIDATION

Pneumocandin B0 (6) and six related lipopeptides are antifungal and anti-Pneumocystis carinii agents from mutants of Zalerion arboricola, whose structures were determined mainly on the basis of spectroscopic analysis. They belong, along with pneumocandin A0 (L-671, 329) previously isolated from thes...

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Published in:	Journal of antibiotics 1992/12/25, Vol.45(12), pp.1875-1885
Main Authors:	HENSENS, OTTO D., LIESCH, JERROLD M., ZINK, DEBORAH L., SMITH, JACK L., WICHMANN, CAROL F., SCHWARTZ, ROBERT E.
Format:	Article
Language:	English
Subjects:	Anti-Bacterial Agents Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Antifungal Agents - chemistry Antifungal Agents - pharmacology Antiviral Agents - chemistry Biological and medical sciences Candida albicans - drug effects Crystallography Echinocandins Magnetic Resonance Spectroscopy Medical sciences Mitosporic Fungi - chemistry Peptides Peptides, Cyclic - chemistry Peptides, Cyclic - pharmacology Pharmacology. Drug treatments Pneumocystis - drug effects Stereoisomerism Structure-Activity Relationship
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cited_by	cdi_FETCH-LOGICAL-c4265-6f4fc6da55f50ba8bfff35c30297d9587f5acb57b1d327ce37ae73d84e4478cd3
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container_end_page	1885
container_issue	12
container_start_page	1875
container_title	Journal of antibiotics
container_volume	45
creator	HENSENS, OTTO D. LIESCH, JERROLD M. ZINK, DEBORAH L. SMITH, JACK L. WICHMANN, CAROL F. SCHWARTZ, ROBERT E.
description	Pneumocandin B0 (6) and six related lipopeptides are antifungal and anti-Pneumocystis carinii agents from mutants of Zalerion arboricola, whose structures were determined mainly on the basis of spectroscopic analysis. They belong, along with pneumocandin A0 (L-671, 329) previously isolated from these laboratories, 1) to the echinocandin class of antifungal agents. The product from base-catalyzed ring opening involving the hemiaminal position of the dihydroxyornithine residue of B0, has been clearly defined as 6b. Modifications were limited to the 3-hydroxy-4-methylproline, 3, 4-dihydroxyhomotyrosine and 4, 5-dihydroxyornithine residues of pneumocandin A0.
doi_str_mv	10.7164/antibiotics.45.1875
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source	J-STAGE (Japan Science & Technology Information Aggregator, Electronic) - Open Access English articles
subjects	Anti-Bacterial Agents Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Antifungal Agents - chemistry Antifungal Agents - pharmacology Antiviral Agents - chemistry Biological and medical sciences Candida albicans - drug effects Crystallography Echinocandins Magnetic Resonance Spectroscopy Medical sciences Mitosporic Fungi - chemistry Peptides Peptides, Cyclic - chemistry Peptides, Cyclic - pharmacology Pharmacology. Drug treatments Pneumocystis - drug effects Stereoisomerism Structure-Activity Relationship
title	PNEUMOCANDINS FROM Zalerion arboricola: III. STRUCTURE ELUCIDATION
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