2-Aryl-3,6-dialkyl-5-dialkylaminopyrimidin-4-ones as novel crf-1 receptor antagonists

The discovery, synthesis and structure–activity studies of a novel series of 2-arylpyrimidin-4-ones as CRF-1 receptor antagonists is described. These compounds are structurally simple and display appropriate physical properties for CNS agents The discovery, synthesis and structure–activity studies o...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2003-08, Vol.13 (15), p.2497-2500
Main Authors: Hodgetts, Kevin J., Yoon, Taeyoung, Huang, Jianhua, Gulianello, Michael, Kieltyka, Andrzej, Primus, Renee, Brodbeck, Robbin, De Lombaert, Stéphane, Doller, Darı́o
Format: Article
Language:English
Subjects:
Biological and medical sciences
Chemical Phenomena
Chemistry, Physical
Drug Design
Humans
In Vitro Techniques
Indicators and Reagents
Medical sciences
Microsomes - drug effects
Neuropharmacology
Neurotransmitters. Neurotransmission. Receptors
Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems
Pharmacology. Drug treatments
Pyrimidines - chemical synthesis
Pyrimidines - pharmacology
Receptors, Corticotropin-Releasing Hormone - antagonists & inhibitors
Structure-Activity Relationship
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Summary:The discovery, synthesis and structure–activity studies of a novel series of 2-arylpyrimidin-4-ones as CRF-1 receptor antagonists is described. These compounds are structurally simple and display appropriate physical properties for CNS agents The discovery, synthesis and structure–activity studies of a novel series of 2-arylpyrimidin-4-ones as CRF-1 receptor antagonists is described.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(03)00483-9