Is Positron Emission Tomography an Accurate Non-invasive Alternative to Sentinel Lymph Node Biopsy in Breast Cancer Patients?

Furthermore, a Canadian study (24) also found low PET sensitivity when evaluating the accuracy of 18F-FDG-PET at detecting axillary lymph node metastases in 41 T1-3 breast cancer patients. All patients underwent pre-operative 18F-FDG-PET scan, SLN biopsy, and ALND. The SLN was examined using serial...

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Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 2003-07, Vol.95 (14), p.1040-1043
Main Authors: Guller, Ulrich, Nitzsche, Egbert, Moch, Holger, Zuber, Markus
Format: Article
Language:English
Subjects:
Axilla
Breast cancer
Breast Neoplasms - diagnostic imaging
Breast Neoplasms - pathology
Female
Fluorodeoxyglucose F18
Humans
Lymph Nodes - diagnostic imaging
Lymph Nodes - pathology
Lymphatic Metastasis - diagnostic imaging
Lymphatic Metastasis - pathology
Medical research
Neoplasm Staging
Predictive Value of Tests
Radiopharmaceuticals
Sensitivity and Specificity
Sentinel Lymph Node Biopsy
Tomography, Emission-Computed - methods
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Summary:Furthermore, a Canadian study (24) also found low PET sensitivity when evaluating the accuracy of 18F-FDG-PET at detecting axillary lymph node metastases in 41 T1-3 breast cancer patients. All patients underwent pre-operative 18F-FDG-PET scan, SLN biopsy, and ALND. The SLN was examined using serial sectioning and IHC using a monoclonal anti-CK antibody (CAM 5.2 clone) in addition to standard H&E staining.
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/95.14.1040