The relative roles of C4A and C4B in prevention of immune precipitation, solubilisation and immune adherence

C4A and C4B levels were measured in serum from 246 normal individuals. Complement-mediated solubilisation, assayed using alkaline phosphatase anti-alkaline phosphatase immune complexes (IC), correlated with both C4A and C4B levels. However, C4A and C4B levels showed no correlation with solubilisatio...

Full description

Saved in:
Bibliographic Details
Published in:Rheumatology international 1992-11, Vol.12 (5), p.187-190
Main Authors: HOLME, E. R, VEITCH, J, JOHNSTON, A, MCKAY, I. C, WHALEY, K
Format: Article
Language:English
Subjects:
Antigen-Antibody Complex - immunology
Biological and medical sciences
Complement C4 - physiology
Complement C4a - analysis
Complement C4a - immunology
Complement C4b - analysis
Complement C4b - immunology
Erythrocytes - metabolism
Fundamental and applied biological sciences. Psychology
Hemolysis
Humans
Immune Adherence Reaction
Precipitin Tests
Receptors, Complement - metabolism
Serum Albumin - immunology
Skeleton and joints
Solubility
Vertebrates: osteoarticular system, musculoskeletal system
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:C4A and C4B levels were measured in serum from 246 normal individuals. Complement-mediated solubilisation, assayed using alkaline phosphatase anti-alkaline phosphatase immune complexes (IC), correlated with both C4A and C4B levels. However, C4A and C4B levels showed no correlation with solubilisation of bovine serum albumin (BSA) ICs, or with the prevention of immune precipitation of BSA or alkaline phosphatase ICs, nor with immune adherence assayed using thyroglobulin and BSA ICs.
ISSN:0172-8172
1437-160X
DOI:10.1007/BF00302150