Germ cell transplantation: a review and progress report on ICSI from spermatozoa generated in xenogeneic testes

Results from the transplantation of donor male germ cells into xenogeneic recipient seminiferous tubules indicate that donor spermatogonia are capable of differentiating to form spermatozoa morphologically characteristic of the donor species. Germ cell transplantation procedures combined with develo...

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Bibliographic Details
Published in:Human reproduction update 2003-05, Vol.9 (3), p.291-307
Main Authors: Sofikitis, N., Kaponis, A., Mio, Y., Makredimas, D., Giannakis, D., Yamamoto, Y., Kanakas, N., Kawamura, H., Georgiou, J., Schrader, M., Lolis, E., Giannakopoulos, X., Loutradis, D., Tarlatzis, V., Miyagawa, I.
Format: Article
Language:English
Subjects:
Animals
Cell Transplantation - methods
Cryopreservation
Humans
Kinetics
Male
Meiosis - physiology
Seminiferous Tubules
Sperm Injections, Intracytoplasmic
Spermatogenesis - physiology
Spermatogonia
Spermatozoa - cytology
Spermatozoa - transplantation
syngeneic
testis
Testis - physiology
Tissue Donors
transplantation
Transplantation, Heterologous
xenogeneic
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Summary:Results from the transplantation of donor male germ cells into xenogeneic recipient seminiferous tubules indicate that donor spermatogonia are capable of differentiating to form spermatozoa morphologically characteristic of the donor species. Germ cell transplantation procedures combined with developments in freezing, culturing or enriching germ cell populations have applications of paramount importance in medicine, basic sciences and animal reproduction. Additionally, these techniques can serve as an alternative approach for gonadal protection and fertility preservation in patients with cancer. This article is a chronological critical review of the technological advances that followed the initial successful transplantation of mouse germ cells into recipient mice. Furthermore, the factors responsible for the immunological privilege properties of the testis and the parameters influencing the potential of mammalian germ cells to undergo mitosis and meiosis within a xenogeneic testis are described. Finally, the role of human germ cell transplantation procedures in the therapeutic management of non‐obstructive azoospermia is discussed.
ISSN:1355-4786
1460-2369
DOI:10.1093/humupd/dmg015