Short-Term Use of Estradiol for Depression in Perimenopausal and Postmenopausal Women: A Preliminary Report

OBJECTIVE: The authors examined the effect of a 4-week course of estrogen therapy on depression in perimenopausal and postmenopausal women. METHOD: Twenty-two depressed women who were either perimenopausal (N=10) or postmenopausal (N=12) received open-label treatment with transdermal 17 -estradiol (...

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Bibliographic Details
Published in:The American journal of psychiatry 2003-08, Vol.160 (8), p.1519-1522
Main Authors: Cohen, Lee S., Soares, Claudio N., Poitras, Jennifer R., Prouty, Jennifer, Alexander, Allison B., Shifren, Jan L.
Format: Article
Language:English
Subjects:
Administration, Cutaneous
Adult
Biological and medical sciences
Climacteric - psychology
Depressive Disorder - drug therapy
Depressive Disorder - psychology
Estradiol - administration & dosage
Estradiol - therapeutic use
Estrogen Replacement Therapy
Estrogens
Female
Hormone replacement therapy
Humans
Medical sciences
Menopause
Mental depression
Middle Aged
Neuropharmacology
Personality Inventory
Pharmacology. Drug treatments
Postmenopause - psychology
Psychiatric Status Rating Scales
Psychiatry
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Treatment Outcome
Women
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Summary:OBJECTIVE: The authors examined the effect of a 4-week course of estrogen therapy on depression in perimenopausal and postmenopausal women. METHOD: Twenty-two depressed women who were either perimenopausal (N=10) or postmenopausal (N=12) received open-label treatment with transdermal 17 -estradiol (100 g day) for 4 weeks. The Montgomery-Åsberg Depression Rating Scale and the Beck Depression Inventory were used to assess depressive symptoms, the Greene Climacteric Scale was used to assess menopause-related symptoms, and the Clinical Global Impression (CGI) was used to assess global clinical improvement in these women at baseline and after treatment. Remission of depression was defined as a score
ISSN:0002-953X
1535-7228
DOI:10.1176/appi.ajp.160.8.1519