Inheritable variable sizes of DNA stretches in the human MHC: conserved extended haplotypes and their fragments or blocks

:  The difference in sizes of conserved stretches of DNA sequence within the major histocompatibility complex (MHC) in human individuals constitutes an underappreciated genetic diversity that has many practical implications. We developed a model to describe the variable sizes of stretches of conserv...

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Bibliographic Details
Published in:Tissue antigens 2003-07, Vol.62 (1), p.1-20
Main Authors: Yunis, E.J., Larsen, C.E., Fernandez-Viña, M., Awdeh, Z.L., Romero, T., Hansen, J.A., Alper, C.A.
Format: Article
Language:English
Subjects:
Alleles
Chromosomes, Human, Pair 6
DNA - genetics
Gene Frequency - immunology
genetic
Genetic Variation
genome
genotype
Haplotypes
Histocompatibility Antigens Class I - genetics
Histocompatibility Antigens Class II - genetics
human
Humans
linkage disequilibrium
Major Histocompatibility Complex
Microsatellite Repeats
Models, Genetic
polymorphism (genetics)
recombination
Tumor Necrosis Factor-alpha - genetics
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Summary::  The difference in sizes of conserved stretches of DNA sequence within the major histocompatibility complex (MHC) in human individuals constitutes an underappreciated genetic diversity that has many practical implications. We developed a model to describe the variable sizes of stretches of conserved DNA in the MHC using the known frequencies of four different kinds of small (
ISSN:0001-2815
1399-0039
DOI:10.1034/j.1399-0039.2003.00098.x