Warangalone, the Isoflavonoid Anti-inflammatory Principle of Erythrina addisoniae Stem Bark

The prenylisoflavone warangalone has been isolated from the bark of Erythrina addisoniae. This compound, previously recognized as a powerful inhibitor of protein kinase A, showed marked effectiveness as an anti-inflammatory on the phospholipase A2-induced paw edema and on the 12-O-tetradecanoylphorb...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2003-06, Vol.66 (6), p.891-893
Main Authors: Talla, Emmanuel, Njamen, Dieudonné, Mbafor, Joseph Tanyi, Fomum, Zacharias Tanee, Kamanyi, Albert, Mbanya, Jean-Claude, Giner, Rosa M, Recio, M. Carmen, Máñez, Salvador, Ríos, José Luis
Format: Article
Language:English
Subjects:
animal models
Animals
anti-inflammatory activity
Anti-Inflammatory Agents, Non-Steroidal - chemistry
Anti-Inflammatory Agents, Non-Steroidal - isolation & purification
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
bark
Biological and medical sciences
Blood Platelets
chemical structure
Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors
cytotoxicity
disease models
Ear
Edema
enzyme activity
Enzyme Inhibitors - pharmacology
Erythrina
Erythrina - chemistry
Erythrina addisoniae
Fabaceae
Female
flavonoids
General pharmacology
Humans
Isoflavones - chemistry
Isoflavones - isolation & purification
Isoflavones - pharmacology
isoflavonoids
Leukocytes - drug effects
Leukotriene B4 - antagonists & inhibitors
Medical sciences
medicinal plants
Mice
Molecular Structure
neutrophils
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Phospholipases A - pharmacology
phytochemicals
Plant Bark - chemistry
plant extracts
Plants, Medicinal - chemistry
prenylisoflavone
prostaglandin synthase
Prostaglandin-Endoperoxide Synthases - metabolism
Rats
Rats, Wistar
stems
warangalone
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Summary:The prenylisoflavone warangalone has been isolated from the bark of Erythrina addisoniae. This compound, previously recognized as a powerful inhibitor of protein kinase A, showed marked effectiveness as an anti-inflammatory on the phospholipase A2-induced paw edema and on the 12-O-tetradecanoylphorbol 13-acetate-induced ear edema in mice, after systemic and local administration, respectively.
ISSN:0163-3864
1520-6025
DOI:10.1021/np020599b