Microvessel Density at Presentation Predicts Subsequent Muscle Invasion in Superficial Bladder Cancer

Purpose: The purpose of this study was to determine whether angiogenesis, as measured by microvessel density (MVD), at presentation is related to subsequent progression of superficial bladder cancer (SBC). Experimental Design: Archived primary bladder tumors from 180 patients were stained with a mon...

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Bibliographic Details
Published in:Clinical cancer research 2003-07, Vol.9 (7), p.2583-2586
Main Authors: GODDARD, Jonathan C, SUTTON, Christopher D, FURNESS, Peter N, O'BYRNE, Kenneth J, KOCKELBERGH, Roger C
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Cell Line, Tumor
Disease Progression
Female
Humans
Image Processing, Computer-Assisted
Male
Medical sciences
Microcirculation
Middle Aged
Multivariate Analysis
Muscles - metabolism
Neoplasm Invasiveness
Neovascularization, Pathologic
Nephrology. Urinary tract diseases
Prognosis
Tumors of the urinary system
Urinary Bladder Neoplasms - blood supply
Urinary Bladder Neoplasms - pathology
Urinary tract. Prostate gland
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Summary:Purpose: The purpose of this study was to determine whether angiogenesis, as measured by microvessel density (MVD), at presentation is related to subsequent progression of superficial bladder cancer (SBC). Experimental Design: Archived primary bladder tumors from 180 patients were stained with a monoclonal antibody against cluster determinant 34 to label vessels. Image analysis was used to count MVD in 30 randomly selected areas in each case. Results: Of the 170 patients evaluated, 37 progressed to muscle invasive disease. A strong association was found between the intensity of angiogenesis and clinical stage, pT1 tumors having a higher MVD than pTa disease. The median MVD was significantly higher at presentation in those patients that subsequently developed progressive SBC than in those that did not progress ( P < 0.0001). pT1 ( P = 0.001), grade 3 disease ( P = 0.002), and MVD ( P = 0.008) were found to predict subsequent disease progression on univariable analysis. Both MVD ( P = 0.007) and pT1 disease ( P = 0.044) remained significant predictive factors for subsequent disease progression on multivariable analysis. Conclusion: MVD in SBC at presentation is significantly higher in those cases that subsequently progress to muscle invasive disease.
ISSN:1078-0432
1557-3265