Evidence for, and taxonomic value of, an arachidonic acid cascade in the lipomycetaceae

By using specific inhibitors of the lipoxygenase and cyclo-oxygenase pathways, arachidonic acid metabolites with similar sensitivities towards these inhibitors as in humans, were detected in Dipodascopsis uninucleata. The taxonomic value of aspirin sensitive arachidonic acid metabolites in the Lipom...

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Bibliographic Details
Published in:Antonie van Leeuwenhoek 1992-11, Vol.62 (4), p.251-259
Main Authors: KOCK, J. L. F, COETZEE, D. J, VAN DYK, M. S, TRUSCOTT, M, BOTHA, A, AUGUSTYN, O. P. H
Format: Article
Language:English
Subjects:
Arachidonic Acid - metabolism
Aspirin - pharmacology
Biological and medical sciences
Fatty Acids - classification
Fundamental and applied biological sciences. Psychology
Humans
Karyotyping
Lipoxygenase Inhibitors - chemistry
Microbiology
Morphology, structure, chemical composition
Mycology
Phenotype
Phylogeny
Prostaglandin-Endoperoxide Synthases - chemistry
Saccharomycetales - classification
Saccharomycetales - genetics
Saccharomycetales - metabolism
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Summary:By using specific inhibitors of the lipoxygenase and cyclo-oxygenase pathways, arachidonic acid metabolites with similar sensitivities towards these inhibitors as in humans, were detected in Dipodascopsis uninucleata. The taxonomic value of aspirin sensitive arachidonic acid metabolites in the Lipomycetaceae was next assessed. No metabolites of which the production is inhibited by aspirin were detected in strains representing the following species: Lipomyces starkeyi, Lipomyces kononenkoae, Lipomyces tetrasporus, Myxozyma melibiosi, Myxozyma mucilagina, Myxozyma kluyveri, Waltomyces lipofer, Zygozyma oligophaga and Zygozyma arxii. The detection of such aspirin sensitive arachidonic acid metabolites in representative strains of Lipomyces anomalus and the genus Dipodascopsis, emphasises the isolated position of these taxa in the genus Lipomyces and the family Lipomycetaceae, respectively. Finally using long chain fatty acid analyses, electrophoretic karyotyping and other phenotypic characters, a phylogenetic scheme is proposed for some genera in the Lipomycetaceae.
ISSN:0003-6072
1572-9699
DOI:10.1007/BF00572592