A critical requirement of interferon γ-mediated angiostasis for tumor rejection by CD8+ T cells

It is thought that tumor rejection by CD8(+) T-cell effectors is primarily mediated by direct killing. We show that rejection of different tumors (fibrosarcoma, ras-transformed fibroblasts, colon carcinoma, and plasmacytoma) by CD8(+) T cells is always preceded by inhibition of tumor-induced angioge...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 2003-07, Vol.63 (14), p.4095-4100
Main Authors: ZHIHAI QIN, SCHWARTZKOPFF, Johannes, PRADERA, Felicia, KAMMERTOENS, Thomas, SELIGER, Barbara, PIRCHER, Hanspeter, BLANKENSTEIN, Thomas
Format: Article
Language:English
Subjects:
3T3 Cells
Animals
Biological and medical sciences
CD8-Positive T-Lymphocytes - immunology
CD8-Positive T-Lymphocytes - metabolism
Fibrosarcoma - blood supply
Fibrosarcoma - immunology
Fibrosarcoma - therapy
Host-tumor relations. Immunology. Biological markers
Immunization
Immunotherapy, Adoptive - methods
Interferon-gamma - biosynthesis
Interferon-gamma - immunology
Medical sciences
Melanoma, Experimental - blood supply
Melanoma, Experimental - immunology
Melanoma, Experimental - therapy
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, Inbred DBA
Neoplasms, Experimental - blood supply
Neoplasms, Experimental - immunology
Neoplasms, Experimental - therapy
Neovascularization, Pathologic - immunology
Neovascularization, Pathologic - prevention & control
Tumors
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Summary:It is thought that tumor rejection by CD8(+) T-cell effectors is primarily mediated by direct killing. We show that rejection of different tumors (fibrosarcoma, ras-transformed fibroblasts, colon carcinoma, and plasmacytoma) by CD8(+) T cells is always preceded by inhibition of tumor-induced angiogenesis. Angiostasis and tumor rejection were observed in perforin but not in IFN-gamma-deficient mice. Furthermore, adoptive transfer of tumor-specific CD8(+) T cells from IFN-gamma-competent mice inhibited angiogenesis of lung metastases in comparison to those from IFN-gamma gene-deficient mice. Taken together with our previous findings, we conclude that IFN-gamma-dependent antiangiogenesis is a general mechanism involved in tumor rejection by CD4(+) and CD8(+) T-cell effectors.
ISSN:0008-5472
1538-7445