Correlation between Symptom Graduation, Tumor Characteristics and Survival in Renal Cell Carcinoma

Objectives: To compare renal tumors with respect to initial clinical presentation and assess the prognostic value of a symptom based classification. Material and Methods: Based on symptoms at diagnosis, 388 renal tumors were stratified into three groups: (1) asymptomatic tumors; (2) tumors with loca...

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Bibliographic Details
Published in:European urology 2003-08, Vol.44 (2), p.226-232
Main Authors: Patard, Jean-Jacques, Leray, Emmanuelle, Rodriguez, Alejandro, Rioux-Leclercq, Nathalie, Guillé, François, Lobel, Bernard
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Carcinoma
Carcinoma, Renal Cell - classification
Carcinoma, Renal Cell - diagnosis
Carcinoma, Renal Cell - mortality
Carcinoma, Renal Cell - surgery
Diagnosis
Female
Follow-Up Studies
Health Status
Humans
Kidney Neoplasms - classification
Kidney Neoplasms - diagnosis
Kidney Neoplasms - mortality
Kidney Neoplasms - surgery
Kidneys
Male
Medical sciences
Middle Aged
Multivariate Analysis
Neoplasm Staging
Nephrectomy
Nephrology. Urinary tract diseases
Prognosis
Proportional Hazards Models
Renal cell
Retrospective Studies
Survival
Survival Analysis
Tumors of the urinary system
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Summary:Objectives: To compare renal tumors with respect to initial clinical presentation and assess the prognostic value of a symptom based classification. Material and Methods: Based on symptoms at diagnosis, 388 renal tumors were stratified into three groups: (1) asymptomatic tumors; (2) tumors with local symptoms (3) tumors with systemic symptoms. The three groups were compared for usual clinical and pathological variables using χ 2-tests and Anova regression, for qualitative and quantitative variables, respectively. Survival assessment was made with univariate and multivariate analysis using the Kaplan–Meier method and Cox regression analysis. Results: The three defined groups were significantly different for all analysed variables except for age, sex ratio and pathological subtype. In univariate analysis: ECOG performance status, symptom classification, tumour size, TNM stage and grade, adrenal, perinephric fat or vein invasion were significant prognostic factors ( p
ISSN:0302-2838
1873-7560
DOI:10.1016/S0302-2838(03)00216-1