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Effect of body weight changes on 24-hour blood pressure and left ventricular mass in hypertension: a 4-year follow-up
Few data are available on the long-term effects of weight loss on 24-h blood pressure (BP) and left ventricular mass in overweight hypertensive patients. A total of 181 never-treated overweight hypertensive subjects (body mass index, 25 to 39 kg/m 2, office BP 145/94 ± 12/7 mm Hg) had 24-h BP monito...
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Published in: | American journal of hypertension 2003-08, Vol.16 (8), p.634-639 |
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Main Authors: | , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that cite this one |
Online Access: | Get full text |
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Summary: | Few data are available on the long-term effects of weight loss on 24-h blood pressure (BP) and left ventricular mass in overweight hypertensive patients.
A total of 181 never-treated overweight hypertensive subjects (body mass index, 25 to 39 kg/m
2, office BP 145/94 ± 12/7 mm Hg) had 24-h BP monitoring and echocardiography twice, at baseline and after 3.8 ± 2 years (minimum 1 year). None of the subjects received antihypertensive drugs during the follow-up. Main outcome measures were changes in 24-h BP and in left ventricular mass.
Percent change in body weight had a direct relationship with 24-h BP changes (
r = 0.35 and 0.31 for systolic and diastolic BP, respectively; both
P < .001). The associations with office BP changes (
r = 0.13,
P = .10 for systolic BP;
r = 0.15,
P = .06 for diastolic BP) were significantly weaker (both
P < .01, z test). The patients who lost weight during follow-up (
n = 106) had a significantly lower increase in 24-h BP (+0.6 ± 9/ +0.2 ± 6
v +4.9 ± 9/ +2.7 ± 7 mm Hg for systolic/diastolic BP, both
P < .01) and in left ventricular mass (−3 ± 30 g
v +9 ± 32 g,
P < .02) than the remaining subjects. In a multiple linear regression, a 10% weight loss independently predicted a 4.3/3.8 mm Hg decrease in 24-h systolic/diastolic BP.
Long-term weight loss determines a sustained BP reduction during the 24 h and a decrease in left ventricular mass in overweight hypertensive subjects. The relation of weight loss with ambulatory BP changes is closer than that with office BP. |
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ISSN: | 0895-7061 1879-1905 1941-7225 |
DOI: | 10.1016/S0895-7061(03)00894-X |