Cytotoxic Activity of Tetraprenylphenols Related to Suillin, an Antitumor Principle from Suillus granulatus

Cytotoxic activity against three tumor cell lines (KB, P-388, and NSCLC-N6) has been determined for 14 natural and semisynthetic tetraprenylphenols. Structure-activity relationships have been examined.

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 1992-12, Vol.55 (12), p.1772-1775
Main Authors: Geraci, Corrada, Piattelli, Mario, Tringali, Corrado, Verbist, Jean-Francois, Roussakis, Christos
Format: Article
Language:English
Subjects:
Animals
ANTINEOPLASTIC AGENT
Antineoplastic Agents, Phytogenic - pharmacology
Basidiomycota - chemistry
Biological and medical sciences
Cell Survival - drug effects
COMPOSE PHENOLIQUE
COMPUESTOS FENOLICOS
CYTOTOXICITY
Diterpenes - pharmacology
EXTRACTOS
EXTRACTS
EXTRAIT
General pharmacology
Humans
KB Cells - drug effects
Leukemia P388 - pathology
Medical sciences
MOLECULAR STRUCTURE
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
PHENOLIC COMPOUNDS
Phenols - pharmacology
STRUCTURE
Structure-Activity Relationship
SUILLUS
TOXICIDAD
TOXICITE
TOXICITY
Tumor Cells, Cultured - drug effects
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Description
Summary:Cytotoxic activity against three tumor cell lines (KB, P-388, and NSCLC-N6) has been determined for 14 natural and semisynthetic tetraprenylphenols. Structure-activity relationships have been examined.
ISSN:0163-3864
1520-6025
DOI:10.1021/np50090a010