The Q7R Saitohin gene polymorphism is not associated with Alzheimer disease

Previous studies have reported conflicting results regarding the association of the Q7R polymorphism in the Saitohin gene with late-onset Alzheimer disease (AD). Given that AD is a tauopathy but no mutations or polymorphisms in Tau have been consistently associated with AD, and that Saitohin is nest...

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Bibliographic Details
Published in:Neuroscience letters 2003-08, Vol.347 (3), p.143-146
Main Authors: Oliveira, Sofia A, Martin, Eden R, Scott, William K, Nicodemus, Kristin K, Small, Gary W, Schmechel, Donald E, Doraiswamy, P.Murali, Roses, Allen D, Saunders, Ann M, Gilbert, John R, Haines, Jonathan L, Vance, Jeffery M, Pericak-Vance, Margaret A
Format: Article
Language:English
Subjects:
Alzheimer Disease - genetics
Association study
Biological and medical sciences
Case-Control Studies
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Genetic Predisposition to Disease
Genotype
Humans
Medical sciences
Neurology
Parkinson disease
Polymorphism
Polymorphism, Genetic
Saitohin
tau Proteins - genetics
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Summary:Previous studies have reported conflicting results regarding the association of the Q7R polymorphism in the Saitohin gene with late-onset Alzheimer disease (AD). Given that AD is a tauopathy but no mutations or polymorphisms in Tau have been consistently associated with AD, and that Saitohin is nested in intron 9 of Tau and shares a similar expression pattern, we tested this association in 690 multiplex AD families and in a case-control sample (903 patients and 320 controls). We found no evidence of significant association of this polymorphism with risk of AD using family-based and case-control tests of association.
ISSN:0304-3940
1872-7972
DOI:10.1016/S0304-3940(03)00670-0