Vascular Endothelial Growth Factor-B Promotes In Vivo Angiogenesis

Vascular endothelial growth factors (VEGFs) and their receptors have emerged as central regulators of the angiogenic process. However, involvement of VEGF-B, one of these factors, in angiogenesis remains obscure. Mice received subcutaneous injection of Matrigel alone or Matrigel with human recombina...

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Bibliographic Details
Published in:Circulation research 2003-07, Vol.93 (2), p.114-123
Main Authors: Silvestre, Jean-Sébastien, Tamarat, Radia, Ebrahimian, Teni G, Le-Roux, Aude, Clergue, Michel, Emmanuel, Florence, Duriez, Micheline, Schwartz, Bertrand, Branellec, Didier, Lévy, Bernard I
Format: Article
Language:English
Subjects:
Animals
Arterioles - drug effects
Biological and medical sciences
Biological Assay
Blood vessels and receptors
Capillaries - drug effects
Cell Count
Cell Division - drug effects
Cell Movement - drug effects
Collagen - metabolism
Drug Combinations
Endothelial Growth Factors - pharmacology
Endothelial Growth Factors - physiology
Female
Fundamental and applied biological sciences. Psychology
Hindlimb - blood supply
Hindlimb - physiopathology
Ischemia - physiopathology
Laminin - metabolism
Male
Matrix Metalloproteinases - metabolism
Mice
Mice, Inbred C57BL
Neovascularization, Physiologic - drug effects
Neovascularization, Physiologic - physiology
Nitric Oxide Synthase - metabolism
Nitric Oxide Synthase Type II
Nitric Oxide Synthase Type III
Phosphorylation
Protein-Serine-Threonine Kinases
Proteoglycans - metabolism
Proto-Oncogene Proteins - metabolism
Proto-Oncogene Proteins c-akt
Signal Transduction - drug effects
Signal Transduction - physiology
Vascular Endothelial Growth Factor B
Vascular Endothelial Growth Factor Receptor-1 - metabolism
Vertebrates: cardiovascular system
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Summary:Vascular endothelial growth factors (VEGFs) and their receptors have emerged as central regulators of the angiogenic process. However, involvement of VEGF-B, one of these factors, in angiogenesis remains obscure. Mice received subcutaneous injection of Matrigel alone or Matrigel with human recombinant protein rhVEGF-B167 or with rhVEGF-A165. After 14 days, cell ingrowth in the Matrigel plug was increased by 2.0- and 2.5-fold in rhVEGF-B167-treated and rhVEGF-A165-treated mice, respectively (P
ISSN:0009-7330
1524-4571
DOI:10.1161/01.RES.0000081594.21764.44