Liver oleic acid biogenesis is impaired during the prehypertensive period in the spontaneously hypertensive rat

• Published in: Prostaglandins, leukotrienes and essential fatty acids leukotrienes and essential fatty acids, 2003-07, Vol.69 (1), p.27-32
• Main Authors: Savelli, J.-L., Narce, M., Fustier, V., Poisson, J.-P.
• Format: Article
• Language: English
• Subjects: Age; Aging; Animals; Animals, Newborn; Arterial hypertension. Arterial hypotension; Biological and medical sciences; Blood and lymphatic vessels; Blood Glucose - analysis; Body Weight; Cardiology. Vascular system; Desaturation; Experimental diseases; Fatty Acid Desaturases - metabolism; Fatty acids; Fatty Acids - analysis; Fundamental and applied biological sciences. Psychology; Hypertension; Hypertension - enzymology; Hypertension - metabolism; Hypertension - physiopathology; Liver; Liver - enzymology; Liver - metabolism; Liver - physiopathology; Male; Medical sciences; Microsomes; Microsomes, Liver - chemistry; Microsomes, Liver - enzymology; Oleic Acid - biosynthesis; Organ Size; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Wistar; Stearoyl-CoA Desaturase; Vertebrates: endocrinology
• ISSN: 0952-3278; 1532-2823
• DOI: 10.1016/S0952-3278(03)00052-8

In the present study, we have investigated the liver microsomal stearic acid Δ9 desaturation, and the fatty acid composition of liver microsomal total lipids in 10- and 30-day-old spontaneously hypertensive rats (SHRs), compared to the normotensive Wistar Kyoto (WKY) control rats. So as to avoid any influence related to the diet, the composition of the milk being different in SHR and WKY strains, the pups were suckled by adoptive normotensive female Wistar. After weaning, the 30-day-old rats were fed a standard commercial diet and then killed. Our results show lower liver microsomal Δ9 desaturase activities in the 10- and 30-day-old SHR versus the WKY of the same age. The fatty acid composition of the SHR liver microsomal total lipids are not in agreement with the changes in the Δ9 desaturase activities at the two studied ages. This phenomenon depends not only on desaturation/elongation but also on other interacting aspects of lipid metabolism including oxidation, substrate availability, acyl exchange, and eicosanoid synthesis, as well as hormonal status.