Spuriously elevated inorganic phosphate level in a multiple myeloma patient

Summary We report the case of a patient with IgG multiple myeloma and pseudohyperphosphatemia. The patient had no clinical features of hyperphosphatemia. Subsequent investigations demonstrated that this hyperphosphatemia was spurious and was caused by a high concentration of the paraprotein. Deprote...

Full description

Saved in:
Bibliographic Details
Published in:Clinical and laboratory haematology 2003-08, Vol.25 (4), p.271-274
Main Authors: Barutçuoǧlu, B., Parildar, Z., Mutaf, I., Habi̇f, S., Bayindir, O.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Chemical Precipitation
False Positive Reactions
Fatal Outcome
Hematologic and hematopoietic diseases
Humans
Immunoglobulin kappa-Chains - analysis
Indicators and Reagents
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Male
Medical sciences
Middle Aged
Molybdenum - chemistry
Multiple myeloma
Multiple Myeloma - blood
Myeloma Proteins - analysis
Phosphates - blood
pseudohyperphosphatemia
Spectrophotometry, Ultraviolet
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Summary We report the case of a patient with IgG multiple myeloma and pseudohyperphosphatemia. The patient had no clinical features of hyperphosphatemia. Subsequent investigations demonstrated that this hyperphosphatemia was spurious and was caused by a high concentration of the paraprotein. Deproteinization of the serum samples by sulfosalicylic acid resulted in normalization of the elevated phosphate values. This pseudohyperphosphatemia resulted from an increase in optic density because of interference between monoclonal immunoglobulin and the molybdic reagent used to determine phosphate in serum. These data indicate that the finding of marked hyperphosphatemia in multiple myeloma patients should always prompt an assay carried out on a deproteinized sample. In addition, knowledge of this phenomenon may avoid confusion, unnecessary testing and obviate confusion in the clinical evaluation of patients with multiple myeloma.
ISSN:0141-9854
1365-2257
DOI:10.1046/j.1365-2257.2003.00524.x