Swimming of pregnant rats at different water temperatures

• Published in: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology Molecular & integrative physiology, 2003-08, Vol.135 (4), p.605-611
• Main Authors: Osorio, R.A.L., Silveira, V.L.F., Maldjian, S., Morales, A., Christofani, J.S., Russo, A.K., Silva, A.C., Piçarro, I.C.
• Format: Article
• Language: English
• Subjects: Animals; Blood Glucose - analysis; Blood Proteins - analysis; Cholesterol - blood; Corticosterone; Corticosterone - blood; Female; Glycemic response; Litter Size; Metabolic responses; Offspring; Pregnancy; Pregnancy, Animal - physiology; Protein; Rats; Rats, Wistar; Rectum - physiology; Swimming; Temperature; Triglycerides; Triglycerides - blood; Water; Weight Gain
• ISSN: 1095-6433; 1531-4332
• DOI: 10.1016/S1095-6433(03)00144-2

We studied the chronic effect of exercise during water immersion, associated with thermal stress (water temperature at 22, 35 and 40 °C) at an intensity of 80% of maximal work load supported in pregnant rats (P) and non-pregnant female rats (NP). P and NP were subdivided into three subgroups according to water temperature during exercise (P22 and NP22; P35 and NP35; P40 and NP40). The animals were submitted to daily swimming sessions of 10–15 min, for 19 days of pregnancy (P) or experimental conditions (NP). Plasma concentration of triglycerides, cholesterol, glucose, total protein, albumin and corticosterone were determined 24 h after the last exercise session. Weight gain and rectal temperature pre- and post-swimming session were also determined. The offspring were examined just after caesarian section on the 20th day of pregnancy to check weight, length and litter size. Pregnant rats showed an increase of triglycerides, reduction of glycemia, total protein and albumin and cholesterol (at 35 °C) when compared to non-pregnant animals. Such effects probably lead to an adequate delivery of substrate to the fetus and prepare the mother for lactation. Daily thermal stress did not modify metabolic responses to exercise in pregnant rats. Results also show a deleterious effect on offspring when the mother is exposed daily to extreme temperatures during swimming. These results suggest that water temperature (cold and hot) in swimming have to be considered to avoid damage in fetal development.