Effects of dietary nutrients and food groups on bone loss from the proximal femur in men and women in the 7th and 8th decades of age

• Published in: Osteoporosis international 2003-06, Vol.14 (5), p.418-428
• Main Authors: KAPTOGE, S, WELCH, A, MCTAGGART, A, MULLIGAN, A, DALZELL, N, DAY, N. E, BINGHAM, S, KHAW, K.-T, REEVE, J
• Format: Article
• Language: English
• Subjects: Aged; Ascorbic Acid - administration & dosage; Biological and medical sciences; Bone Density; Cancer; Diaries; Diet; Exercise; Exercise - physiology; Female; Femur - physiology; Food; Fruit; Humans; Life Style; Male; Medical sciences; Nutrients; Nutrition research; Osteoporosis; Osteoporosis - etiology; Osteoporosis - physiopathology; Physical Fitness; Potassium; Response rates; Sex Factors; Validation studies; Vitamin C; Weight Loss; Women
• ISSN: 0937-941X; 1433-2965
• DOI: 10.1007/s00198-003-1391-6

We measured the impact of diet, anthropometry, physical activity and lifestyle variables on rates of hip bone mineral density (BMD) loss in 470 white men and 474 white women aged 67-79 years at recruitment dwelling in the community. The subjects were recruited from a prospective population-based diet and cancer study (EPIC-Norfolk) in Eastern England. Dietary intake was measured at baseline using 7-day food diaries and used to calculate intakes of some 31 nutrients and 22 food groups. Standardised questionnaires were used to collect data on anthropometry, physical activity and lifestyle variables. BMD loss (percent per annum; % p.a.) was measured using dual-energy X-ray absorptiometry performed on two occasions an average of 3 years apart (range 2-5 years). The mean rate of BMD change at the total hip region was -0.17% p.a. (SD 1.3% p.a.) in men and -0.41% p.a. (SD 1.2% p.a.) in women. In both men and women, weight gain protected against (and weight loss promoted) BMD loss ( P