Effects of a short outpatient rehabilitation treatment on disability of multiple sclerosis patients: A randomised controlled trial

It is well known that neurorehabilitation can reduce disability or improve handicap of people with multiple sclerosis (MS). The aim of this study was to evaluate the effectiveness of a short period (6 weeks) of a tailored, individualised outpatient rehabilitation program in people with progressive M...

Full description

Saved in:
Bibliographic Details
Published in:Journal of neurology 2003-07, Vol.250 (7), p.861-866
Main Authors: PATTI, Francesco, CIANCIO, Maria Rita, CACOPARDO, Manuela, REGGIO, Ester, FIORILLA, Teresa, PALERMO, Filippo, REGGIO, Arturo, THOMPSON, Alan J
Format: Article
Language:English
Subjects:
Adult
Ambulatory Care - methods
Biological and medical sciences
Confidence Intervals
Female
Humans
Male
Medical sciences
Middle Aged
Multiple Sclerosis - physiopathology
Multiple Sclerosis - rehabilitation
Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis
Neurology
Time Factors
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page 866
container_issue 7
container_start_page 861
container_title Journal of neurology
container_volume 250
creator PATTI, Francesco
CIANCIO, Maria Rita
CACOPARDO, Manuela
REGGIO, Ester
FIORILLA, Teresa
PALERMO, Filippo
REGGIO, Arturo
THOMPSON, Alan J
description It is well known that neurorehabilitation can reduce disability or improve handicap of people with multiple sclerosis (MS). The aim of this study was to evaluate the effectiveness of a short period (6 weeks) of a tailored, individualised outpatient rehabilitation program in people with progressive MS. A randomised-controlled trial was undertaken in patients with primary and secondary progressive MS referred to the Centro Sclerosi Multipla of Catania. One hundred and eleven patients were assessed at baseline and at 12 weeks with validated measures of disability (Functional Independence Measure (FIM)) and impairment (Expanded Disability Status Scale (EDSS) and Functional Systems Scale). Of the 111, 58 were randomly assigned to the treatment group and 53 to the control group. All patients had been previously trained in a home exercise program. Both groups were well matched for age, sex, disease duration and severity, disability and quality of life (Short Form-36). At the end of 6 weeks patients allocated to the rehabilitation treatment group showed significant improvement in their level of disability compared with the control group,while the level of impairment did not change. Thirty-two patients of the treatment group and four of the control group improved on the FIM by two or more steps at 12 weeks (p
doi_str_mv 10.1007/s00415-003-1097-x
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_73508887</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>73508887</sourcerecordid><originalsourceid>FETCH-LOGICAL-c306t-d8df201e5cf910e1bf4821a11f94c584db3fd63d5bcae28a97b02776f04d44d33</originalsourceid><addsrcrecordid>eNpdkU9rFTEUxYMo9ln9AG4kCHU39t5J8ibjrpRWhYKbug6Z_KEpmckzyUC79ZObxxsouEou53cONzmEfET4igDDZQHgKDoA1iGMQ_f0iuyQs75DLsbXZAeMQyeY4GfkXSmPACCb8JacYS8lGxnsyN8b752phSZPNS0PKVea1nrQNbil0uwe9BRiqG1OC63Z6TofhTbYUE7a89E8r7GGQ3S0mOhyKqHQLaR8o1c068WmORRnqUlLzSnGdq056PievPE6FvdhO8_J79ub--sf3d2v7z-vr-46w2BfOyut7wGdMH5EcDh5LnvUiH7kRkhuJ-btnlkxGe16qcdhgn4Y9h645dwydk6-nHIPOf1ZXamq7WNcjHpxaS1qYAKklEMDP_8HPqY1L2031aNEjoMUDcITZNpjS3ZeHXKYdX5WCOrYjjq1o1o76tiOemqeT1vwOs3Ovji2OhpwsQG6GB19-zUTygvHR85bNPsHhlWalA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>218141785</pqid></control><display><type>article</type><title>Effects of a short outpatient rehabilitation treatment on disability of multiple sclerosis patients: A randomised controlled trial</title><source>Springer Nature</source><creator>PATTI, Francesco ; CIANCIO, Maria Rita ; CACOPARDO, Manuela ; REGGIO, Ester ; FIORILLA, Teresa ; PALERMO, Filippo ; REGGIO, Arturo ; THOMPSON, Alan J</creator><creatorcontrib>PATTI, Francesco ; CIANCIO, Maria Rita ; CACOPARDO, Manuela ; REGGIO, Ester ; FIORILLA, Teresa ; PALERMO, Filippo ; REGGIO, Arturo ; THOMPSON, Alan J</creatorcontrib><description>It is well known that neurorehabilitation can reduce disability or improve handicap of people with multiple sclerosis (MS). The aim of this study was to evaluate the effectiveness of a short period (6 weeks) of a tailored, individualised outpatient rehabilitation program in people with progressive MS. A randomised-controlled trial was undertaken in patients with primary and secondary progressive MS referred to the Centro Sclerosi Multipla of Catania. One hundred and eleven patients were assessed at baseline and at 12 weeks with validated measures of disability (Functional Independence Measure (FIM)) and impairment (Expanded Disability Status Scale (EDSS) and Functional Systems Scale). Of the 111, 58 were randomly assigned to the treatment group and 53 to the control group. All patients had been previously trained in a home exercise program. Both groups were well matched for age, sex, disease duration and severity, disability and quality of life (Short Form-36). At the end of 6 weeks patients allocated to the rehabilitation treatment group showed significant improvement in their level of disability compared with the control group,while the level of impairment did not change. Thirty-two patients of the treatment group and four of the control group improved on the FIM by two or more steps at 12 weeks (p&lt;0.0001). An improvement by 1 EDSS step occurred in only two patients of the treatment group and in one patient of the control group. Benefits were maintained for a further six weeks. This study demonstrates that a short outpatient rehabilitation treatment improves disability of MS patients, without changing their impairment and confirms the effectiveness of rehabilitation in people with MS.</description><identifier>ISSN: 0340-5354</identifier><identifier>EISSN: 1432-1459</identifier><identifier>DOI: 10.1007/s00415-003-1097-x</identifier><identifier>PMID: 12883930</identifier><identifier>CODEN: JNRYA9</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Adult ; Ambulatory Care - methods ; Biological and medical sciences ; Confidence Intervals ; Female ; Humans ; Male ; Medical sciences ; Middle Aged ; Multiple Sclerosis - physiopathology ; Multiple Sclerosis - rehabilitation ; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis ; Neurology ; Time Factors</subject><ispartof>Journal of neurology, 2003-07, Vol.250 (7), p.861-866</ispartof><rights>2003 INIST-CNRS</rights><rights>Copyright Springer-Verlag 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=14944007$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12883930$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>PATTI, Francesco</creatorcontrib><creatorcontrib>CIANCIO, Maria Rita</creatorcontrib><creatorcontrib>CACOPARDO, Manuela</creatorcontrib><creatorcontrib>REGGIO, Ester</creatorcontrib><creatorcontrib>FIORILLA, Teresa</creatorcontrib><creatorcontrib>PALERMO, Filippo</creatorcontrib><creatorcontrib>REGGIO, Arturo</creatorcontrib><creatorcontrib>THOMPSON, Alan J</creatorcontrib><title>Effects of a short outpatient rehabilitation treatment on disability of multiple sclerosis patients: A randomised controlled trial</title><title>Journal of neurology</title><addtitle>J Neurol</addtitle><description>It is well known that neurorehabilitation can reduce disability or improve handicap of people with multiple sclerosis (MS). The aim of this study was to evaluate the effectiveness of a short period (6 weeks) of a tailored, individualised outpatient rehabilitation program in people with progressive MS. A randomised-controlled trial was undertaken in patients with primary and secondary progressive MS referred to the Centro Sclerosi Multipla of Catania. One hundred and eleven patients were assessed at baseline and at 12 weeks with validated measures of disability (Functional Independence Measure (FIM)) and impairment (Expanded Disability Status Scale (EDSS) and Functional Systems Scale). Of the 111, 58 were randomly assigned to the treatment group and 53 to the control group. All patients had been previously trained in a home exercise program. Both groups were well matched for age, sex, disease duration and severity, disability and quality of life (Short Form-36). At the end of 6 weeks patients allocated to the rehabilitation treatment group showed significant improvement in their level of disability compared with the control group,while the level of impairment did not change. Thirty-two patients of the treatment group and four of the control group improved on the FIM by two or more steps at 12 weeks (p&lt;0.0001). An improvement by 1 EDSS step occurred in only two patients of the treatment group and in one patient of the control group. Benefits were maintained for a further six weeks. This study demonstrates that a short outpatient rehabilitation treatment improves disability of MS patients, without changing their impairment and confirms the effectiveness of rehabilitation in people with MS.</description><subject>Adult</subject><subject>Ambulatory Care - methods</subject><subject>Biological and medical sciences</subject><subject>Confidence Intervals</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multiple Sclerosis - physiopathology</subject><subject>Multiple Sclerosis - rehabilitation</subject><subject>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</subject><subject>Neurology</subject><subject>Time Factors</subject><issn>0340-5354</issn><issn>1432-1459</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><recordid>eNpdkU9rFTEUxYMo9ln9AG4kCHU39t5J8ibjrpRWhYKbug6Z_KEpmckzyUC79ZObxxsouEou53cONzmEfET4igDDZQHgKDoA1iGMQ_f0iuyQs75DLsbXZAeMQyeY4GfkXSmPACCb8JacYS8lGxnsyN8b752phSZPNS0PKVea1nrQNbil0uwe9BRiqG1OC63Z6TofhTbYUE7a89E8r7GGQ3S0mOhyKqHQLaR8o1c068WmORRnqUlLzSnGdq056PievPE6FvdhO8_J79ub--sf3d2v7z-vr-46w2BfOyut7wGdMH5EcDh5LnvUiH7kRkhuJ-btnlkxGe16qcdhgn4Y9h645dwydk6-nHIPOf1ZXamq7WNcjHpxaS1qYAKklEMDP_8HPqY1L2031aNEjoMUDcITZNpjS3ZeHXKYdX5WCOrYjjq1o1o76tiOemqeT1vwOs3Ovji2OhpwsQG6GB19-zUTygvHR85bNPsHhlWalA</recordid><startdate>20030701</startdate><enddate>20030701</enddate><creator>PATTI, Francesco</creator><creator>CIANCIO, Maria Rita</creator><creator>CACOPARDO, Manuela</creator><creator>REGGIO, Ester</creator><creator>FIORILLA, Teresa</creator><creator>PALERMO, Filippo</creator><creator>REGGIO, Arturo</creator><creator>THOMPSON, Alan J</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20030701</creationdate><title>Effects of a short outpatient rehabilitation treatment on disability of multiple sclerosis patients: A randomised controlled trial</title><author>PATTI, Francesco ; CIANCIO, Maria Rita ; CACOPARDO, Manuela ; REGGIO, Ester ; FIORILLA, Teresa ; PALERMO, Filippo ; REGGIO, Arturo ; THOMPSON, Alan J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c306t-d8df201e5cf910e1bf4821a11f94c584db3fd63d5bcae28a97b02776f04d44d33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Ambulatory Care - methods</topic><topic>Biological and medical sciences</topic><topic>Confidence Intervals</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multiple Sclerosis - physiopathology</topic><topic>Multiple Sclerosis - rehabilitation</topic><topic>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</topic><topic>Neurology</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PATTI, Francesco</creatorcontrib><creatorcontrib>CIANCIO, Maria Rita</creatorcontrib><creatorcontrib>CACOPARDO, Manuela</creatorcontrib><creatorcontrib>REGGIO, Ester</creatorcontrib><creatorcontrib>FIORILLA, Teresa</creatorcontrib><creatorcontrib>PALERMO, Filippo</creatorcontrib><creatorcontrib>REGGIO, Arturo</creatorcontrib><creatorcontrib>THOMPSON, Alan J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PATTI, Francesco</au><au>CIANCIO, Maria Rita</au><au>CACOPARDO, Manuela</au><au>REGGIO, Ester</au><au>FIORILLA, Teresa</au><au>PALERMO, Filippo</au><au>REGGIO, Arturo</au><au>THOMPSON, Alan J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of a short outpatient rehabilitation treatment on disability of multiple sclerosis patients: A randomised controlled trial</atitle><jtitle>Journal of neurology</jtitle><addtitle>J Neurol</addtitle><date>2003-07-01</date><risdate>2003</risdate><volume>250</volume><issue>7</issue><spage>861</spage><epage>866</epage><pages>861-866</pages><issn>0340-5354</issn><eissn>1432-1459</eissn><coden>JNRYA9</coden><abstract>It is well known that neurorehabilitation can reduce disability or improve handicap of people with multiple sclerosis (MS). The aim of this study was to evaluate the effectiveness of a short period (6 weeks) of a tailored, individualised outpatient rehabilitation program in people with progressive MS. A randomised-controlled trial was undertaken in patients with primary and secondary progressive MS referred to the Centro Sclerosi Multipla of Catania. One hundred and eleven patients were assessed at baseline and at 12 weeks with validated measures of disability (Functional Independence Measure (FIM)) and impairment (Expanded Disability Status Scale (EDSS) and Functional Systems Scale). Of the 111, 58 were randomly assigned to the treatment group and 53 to the control group. All patients had been previously trained in a home exercise program. Both groups were well matched for age, sex, disease duration and severity, disability and quality of life (Short Form-36). At the end of 6 weeks patients allocated to the rehabilitation treatment group showed significant improvement in their level of disability compared with the control group,while the level of impairment did not change. Thirty-two patients of the treatment group and four of the control group improved on the FIM by two or more steps at 12 weeks (p&lt;0.0001). An improvement by 1 EDSS step occurred in only two patients of the treatment group and in one patient of the control group. Benefits were maintained for a further six weeks. This study demonstrates that a short outpatient rehabilitation treatment improves disability of MS patients, without changing their impairment and confirms the effectiveness of rehabilitation in people with MS.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>12883930</pmid><doi>10.1007/s00415-003-1097-x</doi><tpages>6</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0340-5354
ispartof Journal of neurology, 2003-07, Vol.250 (7), p.861-866
issn 0340-5354
1432-1459
language eng
recordid cdi_proquest_miscellaneous_73508887
source Springer Nature
subjects Adult
Ambulatory Care - methods
Biological and medical sciences
Confidence Intervals
Female
Humans
Male
Medical sciences
Middle Aged
Multiple Sclerosis - physiopathology
Multiple Sclerosis - rehabilitation
Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis
Neurology
Time Factors
title Effects of a short outpatient rehabilitation treatment on disability of multiple sclerosis patients: A randomised controlled trial
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T17%3A54%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20a%20short%20outpatient%20rehabilitation%20treatment%20on%20disability%20of%20multiple%20sclerosis%20patients:%20A%20randomised%20controlled%20trial&rft.jtitle=Journal%20of%20neurology&rft.au=PATTI,%20Francesco&rft.date=2003-07-01&rft.volume=250&rft.issue=7&rft.spage=861&rft.epage=866&rft.pages=861-866&rft.issn=0340-5354&rft.eissn=1432-1459&rft.coden=JNRYA9&rft_id=info:doi/10.1007/s00415-003-1097-x&rft_dat=%3Cproquest_cross%3E73508887%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c306t-d8df201e5cf910e1bf4821a11f94c584db3fd63d5bcae28a97b02776f04d44d33%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=218141785&rft_id=info:pmid/12883930&rfr_iscdi=true