Autoantibody-induced apoptosis as a possible mechanism of autoimmune retinopathy

Circulating antibodies specific to retinal proteins have been associated with retinal dysfunction in patients with retinopathy. Anti-recoverin antibodies found in patients with cancer-associated retinopathy (CAR) represent a unique model to study the relationship between retinal degeneration and aut...

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Bibliographic Details
Published in:Autoimmunity reviews 2003-03, Vol.2 (2), p.63-68
Main Author: Adamus, Grazyna
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Apoptosis - immunology
Autoantibodies - immunology
Autoantibodies - physiology
Calcium-Binding Proteins - immunology
Caspases - physiology
Enolase
Enzyme Activation
Eye Proteins
Hippocalcin
Humans
Lipoproteins
Models, Biological
Nerve Tissue Proteins
Paraneoplastic
Paraneoplastic Syndromes - etiology
Paraneoplastic Syndromes - immunology
Paraneoplastic Syndromes - pathology
Photoreceptor Cells, Vertebrate - immunology
Photoreceptor Cells, Vertebrate - pathology
Recoverin
Retinal Degeneration - immunology
Retinal Degeneration - pathology
Retinal Diseases - etiology
Retinal Diseases - immunology
Retinopathy
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Summary:Circulating antibodies specific to retinal proteins have been associated with retinal dysfunction in patients with retinopathy. Anti-recoverin antibodies found in patients with cancer-associated retinopathy (CAR) represent a unique model to study the relationship between retinal degeneration and autoimmunity. A body of evidence from in vitro and in vivo studies indicates that anti-recoverin autoantibodies are cytotoxic to retinal cells and induce apoptotic death of retinal photoreceptor cells, which leads to the degeneration of the photoreceptor cell layer. Similar to anti-recoverin autoantibodies, antibodies with other retinal specificities induce their target retinal cell death by activating a caspase 3-dependent apoptotic pathway. Thus, autoantibody-induced apoptosis may be a common pathway that leads to retinal death and blindness.
ISSN:1568-9972
1568-9972
DOI:10.1016/S1568-9972(02)00127-1